THE MEMBRANE TRANSPORT OF ASCORBIC ACID *
THE MEMBRANE TRANSPORT OF ASCORBIC ACID *
复制标题
抗坏血酸的膜运输 *
DOI：
--
复制
发表时间：
1975
影响因子：
5.2
通讯作者：
P. Newton
中科院分区：
文献类型：
--
作者：
G. Mann;P. Newton
一个测量脱氢抗坏血酸转运到人红细胞的速率的系统显示出Michaelis-Menten型动力学，在150 muM DHA水平以上时，底物抑制。糖的加入削弱了这种在递减层次中的运输：d -葡萄糖、d -甘露糖、d -木糖、d -半乳糖、l -葡萄糖、d -花生抗坏血酸盐、l -山梨糖和2-脱氧d -核糖。葡萄糖对抗坏血酸运输的影响在生理水平上是显著的。DHA的运输被铜离子加速，并允许脱氢抗坏血酸沿浓度梯度移动。证据支持高血糖会损害细胞内维生素C可用性的假设。
A system for measuring the rate of transport of dehydroascorbate into human red blood cells shows Michaelis-Menten type kinetics with substrate inhibition at levels above 150 muM DHA. The addition of sugars impairs this transport in the diminishing hierarchy D-glucose, D-mannose, D-xylose, D-galactose, L-lyxose, D-araboascorbate, L-sorbose and 2-deoxy-D-ribose. The effect of glucose on transport of ascorbate is marked at physiological levels. Transport of DHA is accelerated by copper ion and allows dehydroascorbate to move against a concentration gradient. The evidence supports the hypotheses proposing that hyperglycemia will impair the intracellular availability of vitamin C.