Genetic correlations between measures of Mycobacterium bovis infection and economically important traits in Irish Holstein-Friesian dairy cows
Genetic correlations between measures of Mycobacterium bovis infection and economically important traits in Irish Holstein-Friesian dairy cows
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DOI：
10.3168/jds.2009-2925
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发表时间：
2010-11-01
影响因子：
3.5
通讯作者：
Berry, D. P.
中科院分区：
文献类型：
--
作者：
Bermingham, M. L.;More, S. J.;Berry, D. P.
牛分枝杆菌是牛结核病（TB）的主要病原。爱尔兰和其他一些国家未能达到无结核病状态，这表明有必要研究补充控制战略。其中一种方法是通过遗传选择来增强对结核病的抵抗力。以前的研究表明，存在相当大的遗传变异的易感性的措施，M。牛感染，确诊为M.牛感染和M.牛纯化蛋白衍生物（PPD）反应性。本研究的目的是估计的遗传和表型之间的相关性，经济上重要的性状和这些措施的M。牛传染病分别对20，148头和17，178头确诊为M.牛感染和M.牛-PPD反应性记录分别可用于纳入分析。第一至第三产次产奶量、脂肪和蛋白质产量、体细胞计数、产犊间隔和存活率以及第一产次身体状况评分记录;可用于1985年至2007年产犊的奶牛。二元线性线性和阈值线性公畜混合模型用于估计（协）方差分量。主要经济性状与M.从线性-线性和阈值-线性父系模型估计的牛感染是相似的。已证实的M.本研究所调查的牛感染和经济重要性状均接近于零。牛分枝杆菌PPD反应性与脂肪产生（0.39）和身体状况评分（0.36）呈遗传正相关，与体细胞评分（-0.34）和存活率（-0.62）呈负相关。因此，选择增加生存可能间接降低易感性M。牛感染，而减少体细胞计数和增加脂肪产量和身体状况评分的选择可能会增加对M.牛传染病
Mycobacterium bovis is the primary agent of tuberculosis (TB) in cattle. The failure of Ireland and some other countries to reach TB-free status indicates a need to investigate complementary control strategies. One such approach would be genetic selection for increased resistance to TB. Previous research has shown that considerable genetic variation exists for susceptibility to the measures of M. bovis infection, confirmed M. bovis infection, and M. bovis-purified protein derivative (PPD) responsiveness. The objective of this study was to estimate the genetic and phenotypic correlations between economically important traits and these measures of M. bovis infection. A total of 20,148 and 17,178 cows with confirmed M. bovis infection and M. bovis-PPD responsiveness records, respectively, were available for inclusion in the analysis. First- to third-parity milk, fat, and protein yields, somatic cell count, calving interval, and survival, as well as first-parity body condition score records; were available on cows that calved between 1985 and 2007. Bivariate linear-linear and threshold-linear sire mixed models were used to estimate (co)variance components. The genetic correlations between economically important traits and the measures of M. bovis infection estimated from the linear-linear and threshold-linear sire models were similar. The genetic correlations between susceptibility to confirmed M. bovis infection and economically important traits investigated in this study were all close to zero. Mycobacterium bovis-PPD responsiveness was positively genetically correlated with fat production (0.39) and body condition score (0.36), and negatively correlated with somatic cell score (-0.34) and survival (-0.62). Hence; selection for increased survival may indirectly reduce susceptibility to M. bovis infection, whereas selection for reduced somatic cell count and increased fat production and body condition score may increase susceptibility to M. bovis infection.