Tissue reaction to Dacron(R) velour and titanium fibre mesh used for anchorage of percutaneous devices
Tissue reaction to Dacron(R) velour and titanium fibre mesh used for anchorage of percutaneous devices
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DOI：
10.1016/0142-9612(96)84946-5
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发表时间：
1996-06-01
期刊：
影响因子：
14
通讯作者：
Jansen, JA
中科院分区：
文献类型：
--
作者：
Paquay, YCGJ;deRuijter, JE;Jansen, JA
Dacron(R) 丝绒通常用于固定经皮装置，例如腹膜透析中使用的导管。然而，出口部位感染使这种透析方法变得复杂，并且被认为与导管的设计有关。在动物实验中，配有钛纤维网来固定植入物的经皮装置不受感染并发症的影响。本研究的目的是比较相同实验条件下软组织对涤纶丝绒和钛纤维网反应的差异。因此，我们将带有涤纶或钛网的植入物皮下放置在山羊的背部。植入物在原位留置了 4 个月。进行组织学和组织形态学评估。研究发现，涤纶内部的软组织反应主要是炎症，而钛网则具有良好的生物相容性。我们得出的结论是，纤维组织向内生长到涤纶套囊中的有限必然是观察到的经皮装置高故障发生率的原因。 (C) 1996 爱思唯尔科学有限公司。
Dacron(R) velour is often used to anchor a percutaneous device, like the catheter used in peritoneal dialysis. However, exit-site infections complicate this method of dialysis and are supposed to be related to the design of the catheter. In animal experiments, a percutaneous device provided with a titanium fibre mesh to anchor the implant was not affected by infectious complications. The purpose of this study was to compare the differences in soft tissue reaction to Dacron velour and titanium fibre mesh under the same experimental conditions. Therefore, we placed implants, provided with either Dacron or titanium mesh, subcutaneously in the dorsum of goats. The implants were left in situ for 4 months. Histological and histomorphological evaluations were performed. It was found that the soft tissue response inside the Dacron was mainly inflammatory, while the titanium mesh evoked good biocompatible behaviour. We concluded that the limited fibrous tissue ingrowth into the Dacron cuff has to be the reason for the observed high failure incidence of a percutaneous device. (C) 1996 Elsevier Science Limited.