Integrated Behavioral Intervention to Improve HIV/AIDS Treatment Adherence and Reduce HIV Transmission
Integrated Behavioral Intervention to Improve HIV/AIDS Treatment Adherence and Reduce HIV Transmission
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DOI：
10.2105/ajph.2010.197608
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发表时间：
2011-03-01
影响因子：
12.7
通讯作者：
Cain, Demetria
中科院分区：
文献类型：
--
作者：
Kalichman, Seth C.;Cherry, Chauncey;Cain, Demetria
目标。我们进行了一项随机临床试验，以测试一种综合行为干预措施，旨在通过提高服药依从性、降低其他性传播感染的风险、最大限度地减少风险补偿信念来加强艾滋病毒治疗作为预防。艾滋病毒/艾滋病患者(n=436)参加了一项随机临床试验，测试旨在与注意力控制条件相比降低艾滋病毒传播风险的强化行为干预。我们使用未公布的药片计数来监测抗逆转录病毒治疗的依从性，并使用计算机访谈来衡量危险行为。综合传播风险降低干预显示，在3个月和6个月的随访中，抗逆转录病毒治疗的依从性增加，与不符合血清的性伴的无保护性行为减少，在9个月的随访期内新诊断的性传播感染减少(调整后的优势比=3.0；P
Objectives. We conducted a randomized clinical trial to test an integrated behavioral intervention designed to enhance using HIV treatment as prevention by improving medication adherence, reducing risks for other sexually transmitted infections, and minimizing risk compensation beliefs.Methods. Individuals living with HIV/AIDS (n=436) participated in a randomized clinical trial testing an intensive behavioral intervention aimed at reducing HIV transmission risks compared with an attention control condition. We used unannounced pill counts to monitor antiretroviral therapy adherence and computerized interviews to measure risk behaviors.Results. The integrated transmission risk reduction intervention demonstrated increased antiretroviral therapy adherence and less unprotected intercourse with nonseroconcordant partners at 3- and 6-month follow-ups as well as fewer new sexually transmitted infections diagnosed over the 9-month follow-up period (adjusted odds ratio=3.0; P