Drug Discrimination and the Analysis of Private Events.
Drug Discrimination and the Analysis of Private Events.
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毒品歧视和私人事件分析。
DOI：
10.1037/bar0000032
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Maguire,DavidR
中科院分区：
文献类型：
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作者：
Kangas,BrianD;Maguire,DavidR
激进行为主义的一个决定性特征是明确地将私人事件作为行为科学中的物质现象包含在内。然而，令人惊讶的是，尽管有很多理论，但在控制实验的行为分析和私人事件的分析中，特别是在非人类动物中，却明显缺乏。一种适用于私人事件研究的技术是药物鉴别。40多年来，药物鉴别程序一直是一种非常有效的工具，它提供了大量关于药物的体内药理学信息，包括受体选择性、效力和疗效。此外，该程序还提供了滥用责任的重要临床前指征。然而，尽管它作为一种药理学工具具有强大的能力，或者可能正是因为它，对其参数、程序要素和变体的实证研究目前还不是一个活跃的研究领域。这篇综述强调了药物歧视程序作为一种强有力的手段来系统地调查利用药物作为内感受刺激的私人事件。除了有机会研究隐私之外，药物鉴别程序的经验评估可能会为基础和临床药理学的未来努力提供信息和改进标准实践。
A defining feature of radical behaviorism is the explicit inclusion of private events as material phenomena within a science of behavior. Surprisingly, however, despite much theorizing, there is a notable paucity within behavior analysis of controlled experimentation and analysis of private events, especially in nonhuman animals. One technique that is amenable to the study of private events is drug discrimination. For over 40 years, drug discrimination procedures have been an incredibly effective tool providing a wealth of in vivo pharmacological information about drugs, including receptor selectivity, potency, and efficacy. In addition, this procedure has provided important preclinical indications of abuse liability. However, despite its prowess as a pharmacologic tool, or perhaps because of it, empirical investigation of its parameters, procedural elements, and variants is not currently an active research domain. This review highlights the drug discrimination procedure as a powerful means to systematically investigate private events by using drugs as interoceptive stimuli. In addition to the opportunity to study privacy, empirical evaluation of the drug discrimination procedure will likely inform and improve the standard practice for future endeavors in basic and clinical pharmacology.