The antibody crossmatch in liver transplantation.
The antibody crossmatch in liver transplantation.
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发表时间：
1986-10
期刊：
影响因子：
3.8
通讯作者：
Robert D. Gordon;J. Fung;Bernd H. Markus;Ira J. Fox;S. Iwatsuki;Carlos O. Esquivel;A. Tzakis;S. Todo;T. Starzl
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文献类型：
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作者：
Robert D. Gordon;J. Fung;Bernd H. Markus;Ira J. Fox;S. Iwatsuki;Carlos O. Esquivel;A. Tzakis;S. Todo;T. Starzl
本文回顾了520例患者的667例第一、第二和第三位同种异体肝脏移植，以确定受体群体反应性抗体（PRA）和供体-受体抗体交叉配型对2年患者和同种异体肝脏移植存活率的影响。无论是高组反应性抗体，还是供体特异性预形成抗体交叉配型阳性，都与初次移植或再移植患者或同种异体肝脏存活率降低无关。两名患者在接受同种异体肝脏移植后立即接受肾脏移植，这两名患者最初的供体特异性抗体交叉配型均为强阳性。肝脏明显去除或中和了循环抗供体抗体，因为同种异体肾移植功能迅速，没有发生超急性排斥反应。
Six hundred sixty-seven first, second, and third orthotopic liver allografts in 520 patients were reviewed to determine the effect of recipient panel-reactive antibody (PRA) and donor-recipient antibody crossmatch on 2-year patient and liver allograft survival rates. Neither a high panel-reactive antibody nor a positive crossmatch for donor-specific preformed antibody was associated with decreased patient or liver allograft survival for primary grafts or retransplants. Two patients have been given kidney transplants immediately after a liver allograft from a donor with whom each patient had an initial strongly positive donor-specific antibody crossmatch. The liver apparently removed or neutralized circulating anti-donor antibody, since the renal allografts functioned promptly and did not experience hyperacute rejection.