Preparation of Personalized-dose Salbutamol Sulphate Oral Films with Thermal Ink-Jet Printing
Preparation of Personalized-dose Salbutamol Sulphate Oral Films with Thermal Ink-Jet Printing
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DOI：
10.1007/s11095-011-0450-5
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发表时间：
2011-10-01
影响因子：
3.7
通讯作者：
Gaisford, Simon
中科院分区：
文献类型：
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作者：
Buanz, Asma B. M.;Saunders, Mark H.;Gaisford, Simon
评价热喷墨给药方法在口腔薄膜上的应用。惠普的打印机墨盒被修改，使含水药物溶液取代了墨水。确定了打印液粘度和表面张力对打印机性能的影响；发现1.1和1.5 mm(2) s（-1）之间的粘度是最佳的，而表面张力对沉积没有影响。建立了硫酸沙丁胺醇的校准曲线，表明药物在乙酸膜上的沉积随浓度呈线性变化（r(2) = 0.9992）。然后使用打印机将沙丁胺醇硫酸盐沉积在马铃薯淀粉制成的口腔薄膜上。结果表明，当在打印头下单次沉积剂量时，测量剂量与理论剂量符合得很好。经过多次试验，测量剂量总是明显小于理论剂量。提出损耗是由纸张处理过程中剪切力对印刷层的侵蚀引起的。损失是可预测的，沉积剂量的变化总是小于片剂和口服糖浆硫酸沙丁胺醇制剂的BP限值。TIJ打印为个性化剂量药物的临时制备提供了一种快速的方法。
To evaluate the use of thermal ink-jetting as a method for dosing drugs onto oral films.A Hewlett-Packard printer cartridge was modified so that aqueous drug solutions replaced the ink. The performance of the printer as a function of print solution viscosity and surface tension was determined; viscosities between 1.1 and 1.5 mm(2) s(-1) were found to be optimal, while surface tension did not affect deposition. A calibration curve for salbutamol sulphate was prepared, which demonstrated drug deposition onto an acetate film varied linearly with concentration (r(2) = 0.9992). The printer was then used to deposit salbutamol sulphate onto an oral film made of potato starch.It was found that when doses were deposited in a single pass under the print head, then the measured dose was in good agreement with the theoretical dose. With multiple passes the measured dose was always significantly less than the theoretical dose. It is proposed that the losses arise from erosion of the printed layer by shearing forces during paper handling. The losses were predictable, and the variance in dose deposited was always less than the BP limits for tablet and oral syrup salbutamol sulphate preparations.TIJ printing offers a rapid method for extemporaneous preparation of personalized-dose medicines.