Regulation of basal cellular physiology by the homeostatic unfolded protein response.
Regulation of basal cellular physiology by the homeostatic unfolded protein response.
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DOI：
10.1083/jcb.201003138
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发表时间：
2010-05-31
期刊：
影响因子：
--
通讯作者：
Hegde RS
中科院分区：
文献类型：
--
作者：
Rutkowski DT;Hegde RS
内质网（ER）的广泛的膜网络在物理上与所有其他细胞区室并列并在功能上与所有其他细胞区室相连。因此，ER必须感知各种不断变化的生理输入，以便调整其众多功能以维持细胞内稳态。越来越多的新工作表明，未折叠蛋白反应（UPR），传统上负责信号蛋白错误折叠应力从ER，已增选为基础细胞稳态的维持。因此，UPR可以被激活，其输出调节，信号远远超出了蛋白质错误折叠的范围。这些发现揭示了UPR不仅通过其在蛋白质折叠中的作用，而且还通过其对细胞生理学的广泛影响而导致疾病。
The extensive membrane network of the endoplasmic reticulum (ER) is physically juxtaposed to and functionally entwined with essentially all other cellular compartments. Therefore, the ER must sense diverse and constantly changing physiological inputs so it can adjust its numerous functions to maintain cellular homeostasis. A growing body of new work suggests that the unfolded protein response (UPR), traditionally charged with signaling protein misfolding stress from the ER, has been co-opted for the maintenance of basal cellular homeostasis. Thus, the UPR can be activated, and its output modulated, by signals far outside the realm of protein misfolding. These findings are revealing that the UPR causally contributes to disease not just by its role in protein folding but also through its broad influence on cellular physiology.
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