Iridoid glucosides and p-coumaroyl iridoids from Viburnum luzonicum and their cytotoxicity
Iridoid glucosides and p-coumaroyl iridoids from Viburnum luzonicum and their cytotoxicity
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DOI：
10.1021/np040138l
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发表时间：
2004-11-01
影响因子：
5.1
通讯作者：
Esumi, T
中科院分区：
文献类型：
--
作者：
Fukuyama, Y;Minoshima, Y;Esumi, T
从台湾高雄采集的吕宋荚蒾干叶的甲醇提取物中分离出四种新的环烯醚萜苷 (1-4) 和七种带有 (E)-或 (Z)-对香豆酰基的新环烯醚萜苷元 (5-11)。新化合物的结构分别为luzonoid A (1)、luzonoid B (2)、luzonoid C (3)、luzonoid D (4)、luzonoid A (5)、luzonoid B (6)、luzonoid C (7)、luzonoid D (8)、luzonoid E (9)、luzonoid F (10)和luzonoid G (11)，通过分析光谱数据并与先前已知的类似物的值进行比较来阐明。在本研究中分离的环烯醚萜类化合物中，糖苷I和2及其苷元5-9对HeLa S3癌细胞表现出中等的抑制活性，而3和4即使在100μM时也没有表现出细胞毒性。
Four new iridoids glucosides (1-4) and seven new iridoid aglycons (5-11) bearing (E)- or (Z)-p-coumaroyl groups were isolated from a methanol extract of the dried leaves of Viburnum luzonicum collected in Kaoshiung, Taiwan. The structures of the new compounds, named luzonoside A (1), luzonoside B (2), luzonoside C (3), luzonoside D (4), luzonoid A (5), luzonoid B (6), luzonoid C (7), luzonoid D (8), luzonoid E (9), luzonoid F (10), and luzonoid G (11), were elucidated by analysis of spectroscopic data and comparison with values for previously known analogues. Among the iridoids isolated in the present study, glucosides I and 2, and their aglycons 5-9, exhibited moderate inhibitory activity against HeLa S3 cancer cells, whereas 3 and 4 showed no cytotoxicity even at 100 muM.