Elov16 is a poor prognostic predictor in breast cancer
Elov16 is a poor prognostic predictor in breast cancer
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DOI：
10.3892/ol.2016.4587
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发表时间：
2016-07-01
期刊：
影响因子：
2.9
通讯作者：
Wu, Chao-Liang
中科院分区：
文献类型：
--
作者：
Feng, Yin-Hsun;Chen, Wei-Yu;Wu, Chao-Liang
长链脂肪酸家族成员6(Elov16)的延长已被证明与胰岛素抵抗、肥胖和脂肪生成有关。此外，据报道，该蛋白在人类肝细胞癌中表达上调，并与非酒精性脂肪性肝炎相关的肝癌的发生有关。超重与绝经后乳腺癌的风险增加和预后不良有关。然而，Elov16的表达与乳腺癌预后之间的关系仍不确定。因此，本研究采用免疫组织化学方法研究乳腺癌根治性切除术后乳腺癌组织中Elov16的表达。在总共70例患者中，37.1%的患者乳腺癌组织中Elov16表达阳性，而62.9%的患者认为Elov16表达阴性。Elov16阳性表达与阳性淋巴结转移和较短的无复发生存期相关。而Elov16的表达与原发灶大小、淋巴结转移、分期、分级、雌激素受体、孕激素受体、HER2和年龄无关。因此，Elov16的阳性表达对于既往曾接受手术的乳腺癌患者来说是一个预后不良的因素，并可能在未来作为一种潜在的治疗手段发挥作用，特别是在肥胖相关疾病的范围内。
Elongation of long chain fatty acids family member 6 (Elov16) has been demonstrated to be involved in insulin resistance, obesity and lipogenesis. In addition, it has been reported that the protein is upregulated in human hepatocellular carcinoma and is implicated in nonalcoholic steatohepatitis-associated liver carcinogenesis. Excess body weight has been associated with an increased risk of postmenopausal breast cancer and poor prognosis. However, the connection between Elov16 expression and outcome of breast cancer remains uncertain. Therefore, the present study- used immunohistochemical analysis to investigate the expression of Elov16 in breast cancer tissues from patients who had undergone curative mastectomy. Out of a total of 70 patients, 37.1% of patients exhibited positive Elov16 expression in breast cancer tissue, whilst 62.9% were considered as negative. Positive Elov16 expression correlated with positive lymph node involvement and shorter recurrence-free survival. However, Elov16 expression had no association with primary tumor size, lymph node metastasis, stage, grade, estrogen receptor, progesterone receptor, HER2 and age. Therefore, positive Elov16 expression is a poor prognostic factor in patients with breast cancer that have previously undergone surgery, and may function as a potential therapeutic approach in the future, particularly in the scope of obesity related disease.