Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version.
Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version.
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DOI：
10.1007/s10157-016-1334-0
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发表时间：
2016-12
影响因子：
2.3
通讯作者：
Narita, Ichiei
中科院分区：
文献类型：
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作者：
Usui, Joichi;Yamagata, Kunihiro;Imai, Eri;Okuyama, Hiroshi;Kajiyama, Hiroshi;Kanamori, Hiroshi;Kaneko, Shuzo;Kono, Emiko;Sakai, Yukinao;Sakai, Norihiko;Sakamaki, Yuichi;Taniguchi, Yoshinori;Nakai, Kentaro;Nishiwaki, Hiroki;Hirata, Sumio;Yamaya, Hideki;Tsuruoka, Shuichi;Terada, Yoshio;Yokoyama, Hitoshi;Wada, Takashi;Narita, Ichiei
在日本，大约八分之一的成年人患有慢性肾脏疾病（CKD），由于该国人口老龄化，患病率预计将急剧上升。在CKD患者中，由于尿量减少和进一步肾脏损害的风险增加，相当多的药物需要减少剂量或停药。因此，即使CKD患者可能会出现各种并发症，但他们的治疗药物量往往不足。此外，经验表明，药物性肾损伤（DKI）加速肾衰竭的进展，但它并没有被表面上列为肾脏疾病的主要原因。在此背景下，DKI的早期发现、预防和治疗对于预防CKD的进展和肾功能衰竭的发展是非常重要的问题。然而，对于CKD患者的DKI的诊断和治疗以及这些患者的剂量调整，目前尚无全面实用的指南。为了满足这一需求，在卫生、劳动和福利部（MHLW）和日本医学研究与发展机构（AMED）的肾脏疾病实践研究项目“加重慢性肾脏疾病的药物性肾损伤的早期检测和治疗”的支持下，制定了DKI的临床实践指南。“本指南是通过对dki进行临床调查，评估临床病理因素，研究治疗方法而制定的
Approximately one in eight adults has chronic kidney disease (CKD) in Japan, and the prevalence rate is expected to rise steeply due to the aging of the population in this country. In patients with CKD, quite a few medications require the dosage reduction or discontinuation because of their reduced urinary excretion and the increased risk of further renal impairment. Therefore, CKD patients are often treated by insufficient amounts of the medications, even though they may suffer from various complications. Moreover, it is empirically known that drug-induced kidney injury (DKI) accelerates the progression of renal failure, while it is not superficially ranked as a primary cause of kidney disease. In this context, the early detection, prevention, and treatment of DKI are very important issue in preventing the progression of CKD and the development of renal failure. However, there are no comprehensive and practical guideline on the diagnosis and treatment of DKI for CKD patients and on dosage adjustments for these patients. In response to this need, a clinical practice guideline for DKI was developed with the support of a Health and Labour Science Research Grant from the Ministry of Health, Labour, and Welfare (MHLW) and the Japan Agency for Medical Research and Development (AMED) for Practical Research Project for Renal Diseases,‘‘Early detection and treatment of drug-induced kidney injury that aggravate chronic kidney disease.’’This guideline was established by doing a clinical survey on DKIs, evaluating clinicopathological factors, investigating the methods of