Mathematical simulation of forced expiration.
Mathematical simulation of forced expiration.
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强制呼气的数学模拟。
DOI：
10.1152/jappl.1988.65.1.14
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Shapiro,AH
中科院分区：
文献类型：
--
作者：
Elad,D;Kamm,RD;Shapiro,AH
通过数学模型模拟了用力呼气过程中的流量限制。该模型借鉴了随附论文中获得的压力-面积定律，以及Shapiro（Trans. ASME J. Biomech. 99：126-147，1977）。这些方法代表了对先前模型的改进，在于1）模拟了改变肺体积和实质-支气管相互依赖的影响; 2）采用了塌陷气道的更真实的表示; 3）通过允许从亚临界流速到超临界流速的平滑过渡而获得朝向流动限制部位的口部的解决方案，然后通过施加弹性跳跃来匹配口腔压力，（从超临界到亚临界流速的突然转变）;（4）努力程度的影响检查了超过产生初始流量限制所需的压力（或真空压力），包括潜在生理限制的影响。
Flow limitation during forced expiration is simulated by a mathematical model. This model draws on the pressure-area law obtained in the accompanying paper, and the methods of analysis for one-dimensional flow in collapsible tubes developed by Shapiro (Trans. ASME J. Biomech. Eng. 99: 126-147, 1977). These methods represent an improvement over previous models in that 1) the effects of changing lung volume and of parenchymal-bronchial interdependence are simulated; 2) a more realistic representation of collapsed airways is employed; 3) a solution is obtained mouthward of the flow-limiting site by allowing for a smooth transition from sub- to supercritical flow speeds, then matching mouth pressure by imposing an elastic jump (an abrupt transition from super- to subcritical flow speeds) at the appropriate location; and 4) the effects of levels of effort (or vacuum pressure) in excess of those required to produce incipient flow limitation are examined, including the effects of potential physiological limitation.