Revascularization with and without Platelet-rich Plasma in Nonvital, Immature, Anterior Teeth: A Pilot Clinical Study
Revascularization with and without Platelet-rich Plasma in Nonvital, Immature, Anterior Teeth: A Pilot Clinical Study
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DOI：
10.1016/j.joen.2012.09.010
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发表时间：
2012-12-01
影响因子：
4.2
通讯作者：
Logani, Ajay
中科院分区：
文献类型：
--
作者：
Jadhav, Ganesh;Shah, Naseem;Logani, Ajay
引言：本研究旨在评价和比较有无富血小板血浆（PRP）的血运重建诱导的成熟。方法：将20例无活力、未成熟前牙患者随机分为2组。在化学机械制备之后，分别在第1组和第2组中诱导在胶原海绵上携带和不携带PRP的血管重建。这些病例在6个月和12个月的时间间隔进行了临床和放射学随访。结果：所有病例临床上均无症状，体征和症状完全消退。放射学上，第2组与第1组相比，在根尖周愈合、根尖闭合和牙本质壁增厚方面有显著差异。然而，两种手术的牙根延长相当。结论：血运重建术是一种保守而有效的诱导无活力、未成熟牙成熟的方法。补充PRP可以潜在地改善这种再生技术的期望生物学结果。（J Endod 2012;38：1581-1587）
Introduction: This study was conducted to evaluate and compare maturogenesis induced by revascularization with and without platelet-rich plasma (PRP). Methods: Twenty patients with nonvital, immature anterior teeth were randomly categorized into 2 groups. Subsequent to chemomechanical preparation, revascularization with and without PRP carried on a collagen sponge was induced in groups 1 and 2, respectively. The cases were followed up clinically and radiographically at 6- and 12-month intervals. Results: Clinically, all cases were asymptomatic with complete resolution of signs and symptoms. Radiographically, there was a marked difference in periapical healing, apical closure, and dentinal wall thickening in group 2 in comparison with group 1. However, root lengthening was comparable for both of the procedures. Conclusions: Revascularization is a conservative and an effective method for inducing maturogenesis in nonvital, immature teeth. Supplementations with PRP can potentially improve the desired biological outcome of this regenerative technique. (J Endod 2012;38:1581-1587)