The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.
The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.
复制标题
编码单纯疱疹病毒 1 型潜伏期相关转录本的基因影响编码凋亡调节蛋白的转录本（Bcl-x(L) 和 Bcl-x(S)）的积累。
DOI：
10.1128/jvi.77.19.10714-10718.2003
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发表时间：
2003
影响因子：
5.4
通讯作者：
Jones,Clinton
中科院分区：
文献类型：
--
作者：
Peng,Weiping;Henderson,Gail;Perng,Guey-Chuen;Nesburn,AnthonyB;Wechsler,StevenL;Jones,Clinton
The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xLtranscript versus the Bcl-xStranscript in Neuro-2A cells. Bcl-xLencodes an antiapoptotic protein, whereas Bcl-xSencodes a proapoptotic protein. Promoting the accumulation of Bcl-xLin neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.
