GENOMIC IMPRINTING OF MASH2, A MOUSE GENE REQUIRED FOR TROPHOBLAST DEVELOPMENT
GENOMIC IMPRINTING OF MASH2, A MOUSE GENE REQUIRED FOR TROPHOBLAST DEVELOPMENT
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DOI：
10.1038/ng0395-235
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发表时间：
1995-03-01
期刊：
影响因子：
30.8
通讯作者：
NAGY, A
中科院分区：
文献类型：
--
作者：
GUILLEMOT, F;CASPARY, T;NAGY, A
小鼠基因Mash2编码一种滋养层祖细胞发育所需的转录因子。Mash2纯合子突变胚胎在胎盘衰竭后10天死亡。这里我们展示了Mash2是基因组印记的。首先，从父亲那里继承野生型等位基因的Mash2+/-胚胎死亡的阶段与阴蒂后8.5天似乎几乎完全抑制的阶段相同。最后，我们已经在基因和物理上将Mash2定位到7号染色体的远端区域，在一个小鼠基因Mash2中，Mash2编码一种转录因子，是形成一系列印记基因所必需的，包括胰岛素-2、胰岛素样生长因子-2和H19。
The mouse gene Mash2 encodes a transcription factor required for development of trophoblast progenitors. Mash2- homozygous mutant embryos die at 10 days post-coitum from placental failure. Here we show that Mash2 is genomically imprinted. First, Mash2+/- embryos inheriting a wild-type allele from their father die at the same stage as appears almost completely repressed by 8.5 days post-coitum. Finally, we have genetically and physically mapped Mash2 to the distal region of chromosome 7, within a The mouse gene Mash2 encodes a transcription factor required for development of cluster of imprinted genes, including insulin-2, insulin-like growth factor-2 and H19.