Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences.
Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences.
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部分体积校正增加了估计的多巴胺D2样受体结合潜力，并减少了成人年龄差异。
DOI：
10.1177/0271678x17737693
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发表时间：
2019-05
期刊：
影响因子：
--
通讯作者：
Samanez-Larkin GR
中科院分区：
文献类型：
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作者：
Smith CT;Crawford JL;Dang LC;Seaman KL;San Juan MD;Vijay A;Katz DT;Matuskey D;Cowan RL;Morris ED;Zald DH;Samanez-Larkin GR
正电子发射断层扫描（PET）相对适中的空间分辨率增加了部分体积效应的可能性，从而可能低估结合电位（BPND）。鉴于整个成年期的结构性灰质损失，部分体积效应在老年可能更成问题，导致高估成人年龄差异。在这里，我们在两项研究中使用不同的高亲和力D2样放射性配体（18 F-Fallypride，11 C-FLB 457）和不同的PET相机分辨率（105 mm，2.5 mm），从不同的网站检查部分容积校正（PVC）的影响。两个数据集的结果显示，PVC增加了估计的BPND，减少了（尽管没有消除）年龄对BPND的影响。正如预期的那样，与较低分辨率数据相比，PVC的影响在较高分辨率数据中较小。使用未校正数据进行的分析控制了每个感兴趣区域的灰质体积，近似了部分但非所有区域的PVC校正数据。总体而言，研究结果表明，PVC通常会增加估计的BPND，并减少成人年龄差异，特别是在使用低分辨率相机时。研究结果表明，过去30年对多巴胺受体可用性的研究，很少有研究使用PVC，可能高估了衰老对多巴胺受体可用性的影响。
The relatively modest spatial resolution of positron emission tomography (PET) increases the likelihood of partial volume effects such that binding potential (BPND) may be underestimated. Given structural grey matter losses across adulthood, partial volume effects may be even more problematic in older age leading to overestimation of adult age differences. Here we examined the effects of partial volume correction (PVC) in two studies from different sites using different high-affinity D2-like radioligands (18 F-Fallypride, 11C-FLB457) and different PET camera resolutions (∼5 mm, 2.5 mm). Results across both data sets revealed that PVC increased estimated BPND and reduced, though did not eliminate, age effects on BPND. As expected, the effects of PVC were smaller in higher compared to lower resolution data. Analyses using uncorrected data that controlled for grey matter volume in each region of interest approximated PVC corrected data for some but not all regions. Overall, the findings suggest that PVC increases estimated BPND in general and reduces adult age differences especially when using lower resolution cameras. The findings suggest that the past 30 years of research on dopamine receptor availability, for which very few studies use PVC, may overestimate effects of aging on dopamine receptor availability.