N-(2,3-dimercaptopropyl)phthalamidic acid (DMPA) increases polonium-210 excretion.
N-(2,3-dimercaptopropyl)phthalamidic acid (DMPA) increases polonium-210 excretion.
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N-(2,3-二巯基丙基)邻苯二甲酰胺酸 (DMPA) 可增加钋 210 的排泄。
DOI：
10.1007/bf01140585
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Aposhian,HV
中科院分区：
文献类型：
--
作者：
Bogdan,GM;Aposhian,HV
钋-210是最危险的放射性核素之一。早在1988年，人们就开始关注人类意外暴露于二硫醇的问题，但目前还没有关于新型二硫醇螯合剂在增加这种放射性重金属排泄方面的有效性的研究。为此，建立了一种安全、有效的测定粪便中α放射性核素~（210）P放射性的方法。雄性SD大鼠腹腔注射~（210）Po（3.33 × 107 cpm/kg），1h后皮下注射5%碳酸氢钠、N-（2，3-二巯基丙基）邻苯二甲酸（DMPA）或内消旋二巯基丁二酸（DMSA）（0.20mmol/kg），观察~（210）Po的排泄。每天重复治疗，持续12天。DMPA和DMSA使210 Po的尿排泄量分别增加8倍和5倍。与其他处理相比，DMPA增加了210 Po的粪便排泄，也降低了放射敏感器官脾脏中210 Po的水平。DMPA（0.20 mmol/kg，静脉注射）使胆汁中210 Po浓度增加5倍。结果表明，DMPA对~（210）Po的螯合和促排作用比DMSA强。
Polonium-210 is one of the most hazardous radionuclides. As recently as 1988, there have been concerns regarding accidental exposures of humans to it. Yet, there have been no studies on the effectiveness of the newer dithiol chelating agents in increasing the excretion of this radioactive heavy metal. In order to accomplish this, a safe and effective method for determining the radioactivity of polonium-210, an a emitter, in the feces was developed. The excretion of polonium-210 was studied by giving male Sprague-Dawley rats210Po (3.33 × 107cpm/kg, intraperitoneal); 1 h later they were given either 5% sodium bicarbonate,N-(2,3-dimercap-topropyl)phthalamidic acid (DMPA) ormeso-dimercaptosuccinic acid (DMSA) (0.20 mmol/kg, subcutaneous). Treatment was repeated daily for 12 days. DMPA and DMSA increased the urinary excretion of210Po, as compared to control animals, 8-fold and 5-fold, respectively. DMPA increased the fecal excretion of210Po compared to the other treatments and also decreased the level of210Po in the spleen, a radiosensitive organ. DMPA (0.20 mmol/kg, intravenous) increased biliary levels of210Po 5-fold compared to controls. The results indicate that DMPA has greater specificity in chelating and increasing the excretion of210Po than DMSA.