Adjusted Survival Curves Improve Understanding of Multivariable Cox Model Results.

Adjusted Survival Curves Improve Understanding of Multivariable Cox Model Results.
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DOI:
10.1016/j.arth.2021.06.002
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发表时间:
2021-10
期刊:
The Journal of arthroplasty
影响因子:
--
通讯作者:
Crowson CS
Crowson CS
中科院分区:
其他
文献类型:
--
作者:
Lundgreen CS;Larson DR;Atkinson EJ;Devick KL;Lewallen DG;Berry DJ;Maradit Kremers H;Crowson CS

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Kaplan-Meier 生存曲线是骨科研究中对结果进行未经调整的组比较的最常用方法。然而,由于患者群体之间混杂因素的不平衡,它们可能会产生误导。 Cox 模型经常用于调整混杂因素,但调整后的生存曲线的图形显示并不常用。我们描述了调整后的生存曲线在骨科研究中有用的情况,描述并使用两种不同的方法来获得调整后的曲线,并说明它们如何能够提高对多变量 Cox 模型结果的理解。我们进一步提供了确定生存曲线需求并执行调整生存曲线的实用策略。
Kaplan-Meier survival curves are the most common method for unadjusted group comparison of outcomes in orthopedics research. However, they may be misleading due to an imbalance of confounders between patient groups. The Cox model is frequently used to adjust for confounders, but graphical display of adjusted survival curves is not commonly utilized. We describe the circumstances when adjusted survival curves are useful in orthopedic research, describe and use two different methods to obtain adjusted curves, and illustrate how they can improve understanding of the multivariable Cox model results. We further provide practical strategies for identifying the need for and performing adjusted survival curves.
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