EFFECTS OF HORMONES ON ERYTHROPOIESIS IN THE HYPOPHYSECTOMIZED RAT
EFFECTS OF HORMONES ON ERYTHROPOIESIS IN THE HYPOPHYSECTOMIZED RAT
复制标题
激素对垂体切除大鼠红细胞生成的影响
DOI：
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发表时间：
1942
期刊：
影响因子：
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通讯作者：
H. A. Charipper
中科院分区：
文献类型：
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作者：
E. Vollmer;A. S. Gordon;H. A. Charipper
几组研究人员(1-8人)对大鼠去脑垂体术后的贫血进行了研究。起初，这种贫血直接归因于缺乏某些脑下垂体部分或激素(I、3、4)。然而，最近，它被解释为由于缺乏几个垂体腺原理(5，6，8)而引起的新陈代谢变化的反映。因此，Meyer和他的合作者(6)证明了生长激素、促甲状腺激素、促肾上腺激素和甲氧西林对去垂体大鼠的造血活性；我们(8)报告了给去垂体的雄性动物注射孕马血清和给去垂体的雄性大鼠注射丙酸睾丸酮可以恢复正常的红细胞计数。这样的结果虽然有趣，但却使问题变得复杂，而不是澄清了。作为阐明这一问题的一个步骤，似乎有必要扩展我们对切除脑垂体的动物的贫血的了解。
THE ANEMIA which occurs in rats after hypophysectomy has been studied by several groups of investigators (1-8). At first this anemia was attributed directly to the lack of some pituitary fraction or hormone (i, 3, 4). More re-cently, however, it has been interpreted as a reflection of metabolic changes resulting from a deficiency of several hypophyseal principles (5, 6, 8). Thus Meyer and his col-leagues (6) have shown that growth, thyrotropic, andrenotropic hormones, and thy-roxine evoked hemopoietic activity in hypophysectomizjed rats; and we (8) have re-ported that pregnant mare serum administered to hypophysectomijjed male animals and testosterone propionate to hypophysectomized rats of either sex can restore the normal red cell counts. Such results, while interesting, have complicated rather than clarified the prob-lem. As a step in the elucidation of the problem, it appeared necessary to extend our knowledge of the anemia of hypophysectomized animals.