Rho GTPase signalling in cell migration.
Rho GTPase signalling in cell migration.
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DOI：
10.1016/j.ceb.2015.08.005
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发表时间：
2015-10
影响因子：
7.5
通讯作者：
Ridley AJ
中科院分区：
文献类型：
--
作者：
Ridley AJ
细胞以多种不同的方式迁移，这取决于它们所处的环境，包括细胞外基质组成、与其他细胞的相互作用和化学刺激。对于所有类型的细胞迁移，Rho GTPase都起着核心作用，尽管每种Rho GTPase的相对贡献取决于环境和细胞类型。在这里，我回顾了我们对Rho GTPases如何促进不同类型迁移的理解的最新进展，比较了板状平台驱动和气泡驱动的迁移模式。我还描述了细胞如何在内皮细胞间迁移。除了众所周知的调控迁移的Rho、Rac和Cdc42，我还讨论了Rho家族中其他不太明确的成员的作用。
Cells migrate in multiple different ways depending on their environment, which includes the extracellular matrix composition, interactions with other cells, and chemical stimuli. For all types of cell migration, Rho GTPases play a central role, although the relative contribution of each Rho GTPase depends on the environment and cell type. Here, I review recent advances in our understanding of how Rho GTPases contribute to different types of migration, comparing lamellipodium-driven versus bleb-driven migration modes. I also describe how cells migrate across the endothelium. In addition to Rho, Rac and Cdc42, which are well known to regulate migration, I discuss the roles of other less-well characterized members of the Rho family.