The search for human obesity genes
The search for human obesity genes
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DOI：
10.1126/science.280.5368.1374
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发表时间：
1998-05-29
期刊：
影响因子：
56.9
通讯作者：
Allison, DB
中科院分区：
文献类型：
--
作者：
Comuzzie, AG;Allison, DB
近年来，人们对遗传因素对肥胖的影响的认识以惊人的速度增长。据估计，人类与肥胖相关的表型中有40%到70%的变异是可遗传的。虽然在动物模型中已经证明了几个单基因突变会导致肥胖，但人类的情况要复杂得多。人类肥胖的最常见形式来自多个基因、环境因素和行为的相互作用，这种复杂的病因学使得寻找肥胖基因特别具有挑战性。本文讨论了目前用于寻找人类肥胖基因的策略以及这些努力的最新成果。
Understanding of the genetic influences on obesity has increased at a tremendous rate in recent years. By some estimates, 40 to 70 percent of the variation in obesity-related phenotypes in humans is heritable. Although several single-gene mutations have been shown to cause obesity in animal models, the situation in humans is considerably more complex. The most common forms of human obesity arise from the interactions of multiple genes, environmental factors, and behavior, and this complex etiology makes the search for obesity genes especially challenging. This article discusses the strategies currently being used to search for human obesity genes and recent promising results from these efforts.