Regional Cerebral Blood Flow and Cerebrovascular Reactivity in Alzheimer's Disease and Vascular Dementia Assessed by Arterial Spin-labeling Magnetic Resonance Imaging
Regional Cerebral Blood Flow and Cerebrovascular Reactivity in Alzheimer's Disease and Vascular Dementia Assessed by Arterial Spin-labeling Magnetic Resonance Imaging
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DOI：
10.2174/156720213804806016
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发表时间：
2013-02-01
影响因子：
2.1
通讯作者：
Shu, Min
中科院分区：
文献类型：
--
作者：
Gao, Yong-Zhe;Zhang, Jun-Jian;Shu, Min
脑血流动力学紊乱（CBF）在阿尔茨海默病（AD）和血管性痴呆（VaD）中都很常见。本研究的目的是探讨这两种类型痴呆患者的区域脑血流量（rCBF）变化和脑血管反应性（CVR）的不同模式。采用经颅多普勒超声（TCD）和动脉自旋标记（ASL）磁共振分别测量大脑中动脉和rCBF的平均血流速度（MFV）。通过MFV或rCBF对5% CO2吸入反应的变化来评估CVR。ASL结果显示，AD组患者双侧额叶和颞叶rCBF显著降低，VaD组患者左侧额叶和颞叶白质rCBF显著降低。rCBF计算的CVR在AD患者双侧额叶皮质受损更严重。相反，TCD测试未能显示两组之间MFV和CVR的显著差异。因此，ASL检测到的静息rCBF变化和对碳吸入的脑血管反应性的不同模式可能作为区分AD和VaD的潜在标志。
Hemodynamic disturbance in cerebral blood flow (CBF) is common in both Alzheimer's disease (AD) and vascular dementia (VaD). The aim of this study is to investigate the different patterns of regional cerebral blood flow (rCBF) change and cerebrovascular reactivity (CVR) in these two types of dementia. Mean flow velocity (MFV) of middle cerebral artery and rCBF were measured by Transcranial Doppler ultrasound (TCD) and arterial spin-labeling (ASL) magnetic resonance, separately. CVR was evaluated by MFV or rCBF change in response to 5% CO2 inhalation. The ASL results showed that, rCBF was significantly lower in both the bilateral frontal and temporal lobes in AD group and lower in left frontal and temporal white matter in patients with VaD. CVR calculated by rCBF was impaired more severely in bilateral frontal cortices in AD. Conversely, TCD tests failed to demonstrate significant difference in MFV and CVR between the two groups. It is concluded that the different patterns detected by ASL in resting rCBF change and cerebrovascular reactivity in response to carbogen inhalation may serve as a potential marker to distinguish AD and VaD.