Evidence that xeroderma pigmentosum cells from complementation group E are deficient in a homolog of yeast photolyase.
Evidence that xeroderma pigmentosum cells from complementation group E are deficient in a homolog of yeast photolyase.
复制标题
来自互补组 E 的着色性干皮病细胞缺乏酵母光裂合酶同源物的证据。
DOI：
10.1128/mcb.9.11.5105-5112.1989
复制
发表时间：
1989
影响因子：
5.3
通讯作者：
Chu,G
中科院分区：
文献类型：
--
作者：
Patterson,M;Chu,G
Xeroderma pigmentosum (XP) patients are deficient in the excision repair of damaged DNA. Recognition of the DNA lesion appears to involve a nuclear factor that is defective in complementation group E (XPE binding factor). We have now identified a factor in the yeastSaccharomyces cerevisiaethat shares many properties with XPE binding factor, including cellular location, abundance, magnesium dependence, and relative affinities for multiple forms of damaged DNA. Yeast binding activity is dependent on photolyase, which catalyzes the photoreactivation of pyrimidine dimers. These results suggest that yeast photolyase may also function as an auxiliary protein in excision repair. Furthermore, XPE binding factor appears to be the human homolog of yeast photolyase.
