Virulence factors of uropathogenic Escherichia coli.
Virulence factors of uropathogenic Escherichia coli.
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DOI：
10.1016/s0924-8579(03)00236-x
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发表时间：
2003-10-01
影响因子：
10.8
通讯作者：
Nagy, G
中科院分区：
文献类型：
--
作者：
Emody, L;Kerenyi, M;Nagy, G
大肠杆菌的毒力因子主要有两种类型：在细胞表面产生的毒力因子和在细胞内产生然后输出到作用部位的毒力因子。表面上的那些包括不同种类的菌毛，其在粘附到宿主细胞表面方面具有作用，但也可能具有其他作用，例如组织侵入、生物膜形成或细胞因子诱导。讨论了细胞壁组分的活性，并描述了几种具有抗宿主细胞活性的输出毒力因子。其他毒力因子使细菌能够在铁限制的环境中生长。
Virulence factors of Escherichia coli are of two main types; those produced on the surface of the cell and those produced within the cell and then exported to the site of action. Those on the surface include different sorts of fimbriae that have a role in adhesion to the surface of host cells but may also have additional roles such as tissue invasion, biofilm formation or cytokine induction. The activities of cell wall components are discussed and several exported virulence factors are described that have anti host cell activities. Others virulence factors enable the bacteria to grow in an environment of iron restriction.