Diastereo- and enantioselective synthesis of novel β-lactam-containing 1,4-benzodiazepines through a ketene-imine cycloaddition reaction
Diastereo- and enantioselective synthesis of novel β-lactam-containing 1,4-benzodiazepines through a ketene-imine cycloaddition reaction
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DOI：
10.1002/ejoc.200300447
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发表时间：
2004-01-30
影响因子：
2.8
通讯作者：
González, J
中科院分区：
文献类型：
--
作者：
del Pozo, C;Macías, A;González, J
已经在构成迄今为止描述的涉及酮亚胺的Staudinger型反应的少数实例之一的方法中合成了并入稠合至1，4-苯并二氮杂七元环的d键的β-内酰胺环的新型三环支架。此外，已经实现了不对称四元中心的产生。这两种“特权结构”在单一化合物中的结合必然会赋予它们有趣的生物学特性。((C)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2004）。
Novel tricyclic scaffolds that incorporate a beta-lactam ring fused to the d bond of a 1,4-benzodiazepine seven-membered ring have been synthesized in a process that constitutes one of the few examples of Staudinger-type reactions involving ketimines described so far. In addition the creation of an asymmetric quaternary center has been achieved. The combination of these two "privileged structures" in a single compound is bound to confer interesting biological properties upon them. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).