Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs
Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs
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DOI：
10.1354/vp.39-1-74
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发表时间：
2002-01-01
影响因子：
2.4
通讯作者：
Moore, PF
中科院分区：
文献类型：
--
作者：
Affolter, VK;Moore, PF
犬组织细胞增殖性疾病包括以不同生物学行为为特征的多种疾病。这些疾病的病因和发病机制在很大程度上尚不清楚。对 39 只犬的局限性和播散性组织细胞肉瘤的临床病理学、形态学和免疫表型特征进行了检查。罗威纳犬、伯恩山犬和猎犬最常受到影响（79%）。局部组织细胞肉瘤（19只狗）来自单一部位，在引流淋巴结中观察到转移性病变。好发部位为四肢皮下及皮下组织，但肿瘤也发生在其他部位，包括脾、肺、脑、鼻腔和骨髓。播散性组织细胞肉瘤（20只狗）是一种多系统疾病，以前被描述为恶性组织细胞增多症，主要影响脾、肺、骨髓、肝脏和淋巴结。局限性和播散性犬组织细胞肉瘤均由多形性肿瘤细胞群组成。 CD1+。在所有速冻样本（31 只狗）中均鉴定出 CD4-、CD11c+、CD11d-、MHC II+、ICAM-1+、Thy-1+/- 肿瘤细胞。这种表型是骨髓树突状抗原呈递细胞谱系的特征。因此，犬的局限性和播散性组织细胞肉瘤很可能是骨髓树突状细胞肉瘤。树突状抗原呈递细胞在个体发育、表型、功能和定位方面是异质细胞群。犬组织细胞肉瘤中涉及的增殖树突状抗原呈递细胞的确切亚系仍有待确定。对八只狗的福尔马林固定组织的表型分析受到可用标记的限制。形态学特征和表型 CD18+。 CD3-和CD79a-是指示可能的组织细胞起源的必须有用的标准。
Canine histiocytic proliferative disorders include a wide spectrum of diseases characterized by different biologic behaviors. The etiology and pathogenesis of these diseases are largely unknown. The clinicopathologic, morphologic and immunophenotypic characteristics of canine localized and disseminated histiocytic sarcoma were examined in 39 dogs. Rottweilers, Bernese Mountain Dogs, and retrievers were most commonly affected (79%). Localized histiocytic sarcomas (19 dogs) arose from a single site, and metastatic lesions were observed in draining lymph nodes. Predilection sites were subcutis and underlying tissues on extremities, but tumors occurred in other locations, including spleen, lung, brain, nasal cavity, and bone marrow. Disseminated histiocytic sarcomas (20 dogs), a multisystem disease previously described as malignant histiocytosis, primarily affected spleen, lungs, bone marrow, liver, and lymph node. Both localized and disseminated canine histiocytic sarcomas were composed of pleomorphie tumor cell populations. CD1+. CD4-, CD11c+, CD11d-, MHC II+, ICAM-1+, Thy-1+/- tumor cells were identified in all snap-frozen samples (31 dogs). This phenotype is characteristic for myeloid dendritic antigen-presenting cell lineage. hence, canine localized and disseminated histiocytic sarcomas are likely myeloid dendritic cell sarcomas. Dendritic antigen-presenting cells are a heterogeneous cell population with regards to their ontogeny, phenotype, function, and localization. The exact sublineage of the proliferating dendritic antigen-presenting cells involved in canine histiocytic sarcomas remains to be determined. Phenotypic analysis of formalin-fixed tissues from eight dogs was limited by available markers. Morphologic features and the phenotype CD18+. CD3-, and CD79a- were the must useful criteria to indicate likely histiocytic origin.