Physical activity, long-term symptoms, and physical health-related quality of life among breast cancer survivors: a prospective analysis.
Physical activity, long-term symptoms, and physical health-related quality of life among breast cancer survivors: a prospective analysis.
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DOI：
10.1007/s11764-007-0014-1
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发表时间：
2007-06-01
期刊：
影响因子：
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通讯作者：
McTiernan, Anne
中科院分区：
文献类型：
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作者：
Alfano, Catherine M;Smith, Ashley Wilder;McTiernan, Anne
导论：许多乳腺癌幸存者经历了持续的身体癌症症状和治疗，可以降低健康相关的生活质量（HRQOL）。这项前瞻性研究调查了一大批不同种族的乳腺癌幸存者的身体活动（PA）、身体症状的发生和HRQOL。材料和方法：幸存者（n = 545），平均在诊断后6个月，在基线（诊断前PA的回顾性报告）、诊断后29个月（诊断后PA）和诊断后39个月（疼痛、激素症状、性兴趣/功能障碍、疲劳、HRQOL的身体亚量表）亲自或通过邮件进行评估。线性回归和协方差分析评估诊断前和诊断后的PA和有症状的癌症后PA变化与HRQOL的关系。结果：更大的诊断前PA与39个月时更好的身体功能相关（β 1.1-2.3；均p < 0.01），但通常与症状无关。较高的诊断后运动/娱乐PA与较少的疲劳和更好的身体功能相关（β值为-0.146,2.21，p均< 0.01）。癌后PA升高与疲劳、疼痛减轻、身体功能改善相关（均p < 0.01）。在中度到剧烈运动/娱乐PA和剧烈运动/娱乐PA之间发现了显著的正相关，而不是家庭活动。西班牙裔和非西班牙裔白人女性的结果相似。讨论/结论：PA的增加，尤其是在癌症后，始终与更好的身体功能和减少疲劳和身体疼痛有关，强调了幸存者中PA推广的必要性。对癌症幸存者的启示：癌症后，幸存者可以通过增加娱乐性PA来减少疲劳和身体疼痛，并能更好地进行日常活动。
INTRODUCTION: Many breast cancer survivors experience persistent physical symptoms of cancer and treatment that can decrease health-related quality of life (HRQOL). This prospective study investigated physical activity (PA), occurrence of physical symptoms, and HRQOL in a large, ethnically-diverse cohort of breast cancer survivors.MATERIALS AND METHODS: Survivors (n = 545), on average 6 months post-diagnosis, were assessed in person or by mail at baseline (retrospective reports of pre-diagnosis PA), at 29 months post-diagnosis (post-diagnosis PA), and at 39 months post-diagnosis (pain, hormone symptoms, sexual interest/dysfunction, fatigue, physical subscales of HRQOL). Linear regression and analysis of covariance assessed the relationships between pre- and post-diagnosis PA and PA change after cancer with symptoms and HRQOL.RESULTS: Greater pre-diagnosis PA was associated with better physical functioning at 39 months (betas 1.1-2.3; all p < 0.01) but was generally unrelated to symptoms. Greater post-diagnosis sports/recreational PA was related to less fatigue and better physical functioning (betas -0.146, 2.21; both p < 0.01). Increased PA after cancer was related to less fatigue and pain and better physical functioning (all p < 0.01). Significant positive associations were found for moderate to vigorous and vigorous sports/recreation PA, not household activity. Results were similar for Hispanic and non-Hispanic White women.DISCUSSION/CONCLUSIONS: Increased PA, especially after cancer, was consistently related to better physical functioning and to reduced fatigue and bodily pain, underscoring the need for PA promotion among survivors.IMPLICATIONS FOR CANCER SURVIVORS: Survivors may be able to decrease fatigue and bodily pain and be better able to pursue daily activities through increasing recreational PA after cancer.