Photophysical and photosensitizing properties of selected cyanines
Photophysical and photosensitizing properties of selected cyanines
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DOI：
10.1016/s1011-1344(02)00325-1
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发表时间：
2002-08-01
影响因子：
5.4
通讯作者：
Kassab, K
中科院分区：
文献类型：
--
作者：
Kassab, K
鉴于其作为光敏剂的可能用途，目前的工作是为了获得有关所选花青的光物理和光生物学特性的详细信息。除CY-IV（3,3'-二乙基-4,4'-氧杂羰花青）外，我们研究的所有花青都在水介质中表现出加速的光漂白，单线态氧的产生较差，并且对白蛋白的光敏活性相对较弱。在细胞水平上，在总能量密度为 30 J/cm(2) 的照射下，所有花青素均对 Balb/c 3T3 细胞表现出显着的光毒性。 CY-III（3,3'-二乙基碳硫氰碘化物）和CY-II（1,1'-二乙基-4,4'-碳硫氰碘化物）似乎是有前途的光敏剂，尽管之前有报道称前者花青的效率低下，而后者的光漂白速度很快。 (C) 2002 Elsevier Science B V 保留所有权利。
The present work has been carried out to obtain detailed information about the photophysical and photobiological properties of selected cyanines, in view of their possible use as photosensitizing agents. All the cyanines studied by us except CY-IV (3,3'-diethyl-4,4'-oxacarbocyanine), expressed an accelerated photobleaching in aqueous medium, a poor generation of singlet oxygen, and a relative weak photosensitizing activity towards albumin. On the cellular level, all cyanines exhibited a significant phototoxicity towards Balb/c 3T3 cells, upon irradiation with a total fluence of 30 J/cm(2). CY-III (3,3'-diethylcarbothiocayanine iodide) and CY-II (1,1'-diethyl-4,4'-carbocyanine iodide) appear to be promising photosensitizers, in spite of previous reports on the inefficiency of the former cyanine, and the rapid photobleaching of the latter compound. (C) 2002 Elsevier Science B V All rights reserved.