Endolymphatic Hydrops Induced by Immune Response of the Endolymphatic Sac: Relation to Perilymph Antibody Levels
Endolymphatic Hydrops Induced by Immune Response of the Endolymphatic Sac: Relation to Perilymph Antibody Levels
复制标题
内淋巴囊免疫反应引起的内淋巴积水：与外淋巴抗体水平的关系
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
S. Tomiyama
中科院分区：
文献类型：
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作者：
S. Tomiyama
本研究探讨了豚鼠内淋巴囊继发性免疫反应在内淋巴积水发生中的作用。在全身性致敏动物中，直接对囊进行二次匙孔血蓝蛋白（KLH）激发后，1周内迅速发生水肿，然后在4周内逐渐减少。5周后，水肿逐渐复发并再次发展。平均外淋巴抗KLH抗体水平从第1天到第4周上升，然后下降。第2天外淋巴抗KLH抗体水平升高是由于血管通透性增加，第7天后通过囊的挑战进行局部再生。水肿的发展与第1天至第7天期间的平均外淋巴抗KLH抗体水平相关。2周后，两者之间无相关性。这些结果表明，免疫反应的囊可能会导致过度分泌的内淋巴在初始阶段，并可能进一步导致不可逆的功能障碍的囊在以后的阶段。
This study investigated the effect of a secondary immune response in the endolymphatic sac on the development of endolymphatic hydrops in guinea pigs. Following secondary keyhole limpet hemocyanin (KLH) challenge directly to the sac in systemically presensitized animals, hydrops rapidly developed within 1 week, then gradually reduced by 4 weeks. After 5 weeks, hydrops gradually recurred and developed again. Mean perilymph anti-KLH antibody levels rose from day 1 to 4 weeks and then decreased. The elevation of perilymph anti-KLH antibody levels on day 2 was due to an increased vascular permeability and there was a local regeneration by the challenge of the sac after day 7. The development of hydrops correlated well with mean perilymph anti-KLH antibody levels in the period from day 1 to day 7. After 2 weeks, there was no correlation between them. These results suggest that an immune response of the sac may induce an excess secretion of endolymph in the initial stage and may further lead to irreversible dysfunction of the sac at a later stage.
内淋巴囊直接抗原攻击后内耳抗体水平升高。
影响因子：
1.4
作者：
Tomiyama,S;Harris,JP
通讯作者：
Harris,JP