The urinary symptoms and neurological disabilities are differentially correlated between multiple sclerosis and neuromyelitis optica.
The urinary symptoms and neurological disabilities are differentially correlated between multiple sclerosis and neuromyelitis optica.
复制标题
多发性硬化症和视神经脊髓炎之间的泌尿系统症状和神经功能障碍存在差异相关性。
DOI：
10.1111/cen3.12279
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发表时间：
2016
影响因子：
--
通讯作者：
Kuwabara S.
中科院分区：
文献类型：
--
作者：
Yamamoto T;Mori M;Uzawa A;Uchiyama T;Sakakibara R;Yanagisawa M;Ohno S;Nomura F;Kuwabara S.
众所周知，膀胱功能障碍在多发性硬化症（MS）患者中很常见。排尿功能障碍在视神经肌萎缩症（NMO）中是显著的。然而，MS和NMO之间泌尿系统症状的差异仍然未知。我们计划阐明这两种情况之间的差异，使用泌尿系统症状questionnaire.MethodsWe招募了34例MS和14例NMO患者，他们在神经科，千叶大学医院进行了检查。我们进行了以下泌尿系统症状问卷调查：（i）膀胱过度活动症症状评分（OABSS）;（B）国际前列腺症状评分（IPSS）。神经功能（扩展残疾状态量表的评价）和神经放射学examines.ResultsThe平均得分OABSS和IPSS的患者NMO倾向于更高，无统计学意义。NMO组IPSS生活质量评分明显高于正常对照组。MS患者的扩展残疾状态量表评价与IPSS评分呈正相关，而NMO患者的扩展残疾状态量表评价与IPSS评分呈负相关。多元线性回归分析表明，存在的颈脊髓病变和中央病变涉及灰质与泌尿症状的严重程度。结论泌尿症状往往是更严重的患者与NMO相比，与MS患者的泌尿症状和神经功能障碍似乎与MS和那些与NMO患者之间的差异相关。
ObjectiveIt is well‐known that bladder dysfunction is common in patients with multiple sclerosis (MS). Voiding dysfunction is remarkable in neuromyelitis optica (NMO). However, the difference in the urinary symptoms between MS and NMO remain unknown. We planned to elucidate the differences between the two conditions using a urinary symptoms questionnaire.MethodsWe recruited 34 patients with MS and 14 patients with NMO, who were examined at the Department of Neurology, Chiba University Hospital. We administered the following urinary symptom questionnaires: (i) Overactive Bladder Symptom Score (OABSS); and (b) International Prostate Symptom Score (IPSS). Neurological (Evaluation of the Expanded Disability Status Scale) and neuroradiological examinations were also carried out.ResultsThe mean score of OABSS and IPSS tended to be higher in patients with NMO without statistical significance. The score of IPSS quality of life was significantly higher in patients with NMO. A positive correlation was found between the Evaluation of the Expanded Disability Status Scale and IPSS scores in patients with MS, whereas a negative correlation was found between the Evaluation of the Expanded Disability Status Scale and IPSS scores in patients with NMO. Multiple linear regression analysis showed that the presence of a cervical spinal cord lesion and the central lesion involving gray matter was associated with the severity of urinary symptoms.ConclusionsThe urinary symptoms tended to be more severe in patients with NMO as compared with patients with MS. The urinary symptoms and neurological disabilities seemed to be differentially correlated between patients with MS and those with NMO.