Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?
Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?
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DOI：
10.1007/s00330-009-1689-7
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发表时间：
2010-06-01
影响因子：
5.9
通讯作者：
Regatte, Ravinder
中科院分区：
文献类型：
--
作者：
Friedrich, Klaus M.;Shepard, Timothy;Regatte, Ravinder
评估内侧骨关节炎（OA）临床症状患者的股胫软骨T2值与膝关节对线之间的关系。（平均年龄+/-标准差，62.5 +/- 9.9岁），临床症状为内侧膝关节OA，12例股胫关节内翻，12例股胫关节外翻，在3 T MR上使用2D多回波自旋回波（MESE）序列进行T2映射。采用协方差分析、斯皮尔曼相关系数、精确Mann-Whitney检验和Fisher精确检验进行统计学分析，总的来说，内侧间室软骨的T2值（中位数+/-四分位距，49.44 +/- 6.58）显著高于外侧间室（47.15 +/- 6.87）（P = 0.0043）。内翻对线患者（50.83 +/- 6.30 ms）的软骨T2值显著高于外翻对线患者（46.20 +/- 6.00 ms）（P < 0.0001）。内翻组和外翻组的软骨T2值与Kellgren Lawrence评分之间无统计学显著相关性，内翻组内侧膝关节骨性关节炎患者T2测量值增加，进一步支持骨性关节炎与关节对线相关的理论。
To assess the relationship between T2 values of femorotibial cartilage and knee alignment in patients with clinical symptoms of medial osteoarthritis (OA).Twenty-four patients (mean age +/- standard deviation, 62.5 +/- 9.9 years) with clinical symptoms of medial knee OA, 12 with varus and 12 with valgus alignment of the femorotibial joint, were investigated on 3T MR using a 2D multi-echo spin echo (MESE) sequence for T2 mapping. Analysis of covariance, Spearman correlation coefficients, exact Mann-Whitney tests, and Fisher's exact tests were used for statistical analysis.Overall the T2 values of cartilage in the medial compartment (median +/- interquartile-range, 49.44 +/- 6.58) were significantly higher (P = 0.0043) than those in the lateral compartment (47.15 +/- 6.87). Patients with varus alignment (50.83 +/- 6.30 ms) had significantly higher T2 values of cartilage (P < 0.0001) than patients with valgus alignment (46.20 +/- 6.00 ms). No statistically significant association between the T2 values of cartilage (in either location) and the Kellgren Lawrence score was found in the varus or in the valgus group.T2 measurements were increased in medial knee OA patients with varus alignment, adding support to the theory of an association of OA and joint alignment.