Increased risk of chronic liver disease in patients with major depressive disorder: A population-based study
Increased risk of chronic liver disease in patients with major depressive disorder: A population-based study
复制标题
DOI：
10.1016/j.jad.2019.03.070
复制
发表时间：
2019-05-15
影响因子：
6.6
通讯作者：
Lin Ching-Heng
中科院分区：
文献类型：
--
作者：
Hsu Jer-Hwa;Chien I-Chia;Lin Ching-Heng
目的：本研究调查了重度抑郁症（MDD）患者慢性肝病的患病率和发病率，并旨在确定相关因素。方法：从2005年国家卫生研究所数据库中随机抽取766,427名年龄≥ 18岁的成年受试者。该研究首先在2005年检索了至少有一个MDD主要诊断的受试者，然后还确定了那些主要或次要诊断为慢性肝病的受试者。分析2005年MDD患者与普通人群慢性肝病患病率及其相关因素的差异。比较2006 - 2010年MDD患者与普通人群慢性肝病的患病率。结果：2005年MDD患者慢性肝病患病率是普通人群的2.27倍（12.4%对5.8%;比值比（OR）=2.27; 95%置信区间（CI）=2.07-2.48）。2006-2010年，重度抑郁症患者慢性肝脏疾病的平均年发病率也高于普通人群（2.6%比1.7%;风险比（RR）=1.52; 95%CI =1.37-1.7）。结论：重度抑郁症患者的慢性肝脏疾病患病率和发病率明显高于普通人群。在MDD患者中，年龄较大、男性、糖尿病、高脂血症和使用第一代抗精神病药物是慢性肝病的相关因素。
Objective: This study investigated the prevalence and incidence of chronic liver disease in patients with major depressive disorder (MDD), and aimed to identify associated factors.Methods: Data of 766,427 adult subjects aged >= 18 years were randomly selected from the National Health Research Institute database from the year 2005. The study first searched for subjects with at least one primary diagnosis of MDD in 2005, and then for those with a primary or secondary diagnosis of chronic liver disease were also identified. The differences in the prevalence of chronic liver disease and its associated factors between patients with MDD and the general population in 2005 were then analyzed. We also compared the incidence of chronic liver disease in patients with MDD and in the general population from 2006 to 2010.Results: The prevalence of chronic liver disease in patients with MDD was 2.27 times as high as that of the general population in 2005 (12.4% vs. 5.8%; odds ratio (OR)=2.27; 95% confidence interval (CI)=2.07-2.48). The average annual incidence of chronic liver disease in patients with MDD during 2006-2010 was also higher than that of the general population (2.6% vs. 1.7%; risk ratio (RR)=1.52; 95% CI=1.37-1.7).Conclusions: Patients with MDD had a significantly higher prevalence and incidence of chronic liver disease than the general population. Among patients with MDD, an older age, the male sex, diabetes, hyperlipidemia and first-generation antipsychotic use were factors associated with chronic liver disease.