Light-Responsive Block Copolymer Micelles
Light-Responsive Block Copolymer Micelles
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DOI：
10.1021/ma300094t
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发表时间：
2012-02
期刊：
影响因子：
5.5
通讯作者：
Yue Zhao
中科院分区：
文献类型：
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作者：
Yue Zhao
光响应性嵌段共聚物（BCP）胶束在水溶液中的缔合状态可以被光改变，通常是可逆的。由于其在药物控释方面的潜在应用，这类刺激响应性聚合物胶束受到了越来越多的关注。这一展望突出了近年来取得的进展。一方面，我们讨论了合理的BCP设计的不同方法，利用各种光致变色部分和光化学反应，以及导致BCP胶束的光诱导破坏的潜在机制。另一方面，我们建议在这一领域的未来可能的方向，包括探索新的机制和化学和解决方案的激发波长的问题至关重要的生物医学应用。
The association state of light-responsive block copolymer (BCP) micelles in aqueous solution can be altered, often reversibly, by light. Driven by the potential application in controlled drug delivery, this type of stimuli-responsive polymer micelles has received increasing attention. This Perspective highlights the progress achieved in recent years. On the one hand, we discuss the different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles. On the other hand, we suggest possible future directions in this area, including exploration of new mechanisms and chemistry and solutions to the excitation wavelength problem crucial for biomedical applications.