WHAT IF MINKOWSKI HAD BEEN AGEUSIC - AN ALTERNATIVE ANGLE ON DIABETES
WHAT IF MINKOWSKI HAD BEEN AGEUSIC - AN ALTERNATIVE ANGLE ON DIABETES
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DOI：
10.1126/science.1439783
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发表时间：
1992-10-30
期刊：
影响因子：
56.9
通讯作者：
MCGARRY, JD
中科院分区：
文献类型：
--
作者：
MCGARRY, JD
尽管经过数十年的深入研究，糖尿病相关代谢紊乱的基本病理生理学机制仍然难以捉摸。这里探讨的是，这一领域的传统概念是否有可能重点不对。有人建议，胰岛素抵抗和高血糖症的现象可能会更容易理解，如果在基础脂质代谢异常的背景下。
Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.