Distinguish the Stable and Unstable Plaques Based on Arterial Waveform Analysis
Distinguish the Stable and Unstable Plaques Based on Arterial Waveform Analysis
复制标题
DOI：
10.1016/j.prostr.2019.07.002
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
M. Abdulsalam;Jiling Feng
中科院分区：
文献类型：
--
作者：
M. Abdulsalam;Jiling Feng
由动脉粥样硬化形成的不稳定斑块的破裂是促成中风事件的主要因素。根据2017年中风协会的数据，中风是英国第四大死亡原因。斑块组成百分比对斑块稳定性起重要作用，并且可以被认为是确定患者是否需要手术的重要信息。这项工作的主要目的是确定斑块组成和动脉波形之间存在的关系，以区分稳定和易损斑块。本文用动脉系统的离体实验研究了动脉粥样硬化成分对动脉波形传播的影响。人工颈动脉内植入人工斑块。同时测量动脉斑块部位近端的压力、速度和动脉血管壁运动。波强度分析（WIA）用于将波分离为前向波和后向波，以确定斑块成分将如何影响反射的动脉波形。我们的结果表明，稳定的斑块引起更强的反射波，导致更高的振幅的动脉直径波形。总的来说，这项研究表明，动脉波形与动脉斑块的成分密切相关，这意味着动脉波形可以提供表征斑块类型的信息，从而导致一种新的方法来分层动脉粥样硬化患者并确定是否需要介入血管手术。
The rupturing of unstable plaques, formed by atherosclerosis, is the main factor contributing to the stroke event. According to stroke association in 2017, the stroke is the fourth leading cause of death in the UK. The percentage of plaque composition plays an important role for plaque stability and can be considered as important information to determine whether the patients need surgery or not. The main aim of this work is to determine the relationship that exists between plaque composition and arterial waveform for distinguishing stable and vulnerable plaques. Anin-vitroexperiment, representing the arterial system, is used to investigate the effect of the composition of the atherosclerosis on the propagation of the arterial waveforms. Different types of the artificial plaque, fabricated manually, were implemented into the artificial carotid artery. The pressure, velocity and arterial vessel wall movement were measured simultaneously proximal to the site of the arterial plaques. Wave intensity analysis (WIA) was used to separate the waves into forward and backward waves to identify how the plaque compositions will affect the reflected arterial waveforms. Our results indicated that stable plaques caused the stronger reflected waves, leading to the higher amplitude of the arterial diameter waveform. In general, this study demonstrated that the arterial waveforms are strongly associated with the compositions of the arterial plaques, implying the arterial waveform could provide the information to characterize the types of the plaques, then leading to a novel approach to stratify the atherosclerosis patients and determine if the interventional vascular surgery is needed.