Coffee consumption and the risk of colorectal cancer by anatomical subsite in Japan: Results from the HERPACC studies.
Coffee consumption and the risk of colorectal cancer by anatomical subsite in Japan: Results from the HERPACC studies.
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日本的咖啡消费量和按解剖亚部位划分的结直肠癌风险：HERPACC 研究结果。
DOI：
10.1002/ijc.30746
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发表时间：
2017
影响因子：
6.4
通讯作者：
Keitaro Matsuo.
中科院分区：
文献类型：
--
作者：
Hiroko S Nakagawa;Hidemi Ito;Satoyo Hosono;Isao Oze;Hideo Tanaka;Keitaro Matsuo.
咖啡是一种全球流行的饮料，其消费与较低的结直肠癌（CRC）风险有关。虽然结直肠癌的解剖亚位点表现出不同的生物学特性，咖啡对结直肠癌的解剖亚位点的可能异质性影响仍不清楚。在这里，我们进行了两项病例对照研究，使用爱知癌症中心I和II（HERPACC-I和II）医院流行病学研究计划的数据，检查咖啡消费与CRC风险之间的关联，以及日本人的解剖亚位点风险。受试者在1988年至2000年期间入组HERPACC-I，在2001年至2005年期间入组HERPACC-II。咖啡消费量是通过自填问卷来测量的。采用条件Logistic回归模型计算CRC与咖啡摄入量的比值比（OR），并对年龄、吸烟、饮酒、红肉摄入、BMI、运动、CRC家族史和糖尿病史等潜在混杂因素进行调整。我们通过使用固定效应模型汇总研究特定OR来估计汇总OR。总共纳入了2，696例CRC病例和13，480例非癌症门诊患者作为对照。总体而言，与不饮酒者相比，CRC低于1杯/天、1-2杯/天和3杯或更多杯/天的OR分别为0.88（95% CI：0.77-1.00）、0.90（95% CI：0.80-1.01）和0.78（95% CI：0.65-0.92）（趋势-p= 0.009）。亚位点特异性分析显示，咖啡摄入量与远端结肠癌之间存在显著的反向线性趋势（p趋势= 0.048），直肠癌风险呈降低趋势（p趋势= 0.068）。这些发现表明，咖啡消费可能会影响CRC的预防，特别是远端结肠癌。
Consumption of coffee, a popular beverage worldwide, has been associated with lower colorectal cancer (CRC) risk. Although CRC exhibits different biological characteristics by anatomical subsite, the possibly heterogeneous impact of coffee on CRC by anatomical subsite has remained unclear. Here, we conducted two case‐control studies to examine the association between coffee consumption and CRC risk as well as risk by anatomic subsite among Japanese using data from the Hospital‐based Epidemiological Research Program at Aichi Cancer Center I and II (HERPACC‐I and II). Subjects were enrolled in HERPACC‐I between 1988 and 2000 and in HERPACC‐II between 2001 and 2005. Coffee consumption was measured with a self‐administered questionnaire. A conditional logistic regression model was used to calculate odds ratios (ORs) of CRC with coffee consumption, adjusted for potential confounders of age, smoking, alcohol drinking, red meat intake, BMI, exercise, family history of CRC, and diabetes mellitus history. We estimated summary ORs by pooling study‐specific ORs with a fixed effects model. In total, 2,696 CRC cases and 13,480 non‐cancer outpatients as controls were included. Overall, compared to non‐drinkers, ORs of less than 1 cup/day, 1–2 cups/day and 3 or more cups/day for CRC were 0.88 (95% CI: 0.77–1.00), 0.90 (95% CI: 0.80–1.01) and 0.78 (95% CI: 0.65–0.92), respectively (trend‐p= 0.009). Subsite‐specific analysis revealed a significant inverse linear trend between coffee consumption and distal colon cancer (p‐trend = 0.048), and a tendency toward a lower risk of rectal cancer (p‐trend = 0.068). These findings suggest that coffee consumption might impact the prevention of CRC, especially distal colon cancer.