C-reactive protein levels among women of various ethnic groups living in the United States - (from the Women's Health Study)
C-reactive protein levels among women of various ethnic groups living in the United States - (from the Women's Health Study)
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DOI：
10.1016/j.amjcard.2004.01.067
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发表时间：
2004-05-15
影响因子：
2.8
通讯作者：
Ridker, PM
中科院分区：
文献类型：
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作者：
Albert, MA;Glynn, RJ;Ridker, PM
研究人员比较了24,455名白色、475名黑人、357名亚洲人和254名西班牙裔女性的C反应蛋白（CRP）水平分布，所有这些女性都是妇女健康研究的参与者。黑人女性的中位CRP水平（2.96 mg/L，四分位距[IQR] 1.19 - 5.86）显著高于白色女性（2.02 mg/L，IQR 0.81 - 4.37）、西班牙裔女性（2.06 mg/L，IQR 0.88 - 4.88）和亚裔女性（1.12 mg/L，IQR 0.48 - 2.25）。正如预期的那样，接受激素替代治疗的女性基线CRP水平高于未接受激素替代治疗的女性。在低密度脂蛋白胆固醇或总胆固醇水平上，没有观察到种族之间的差异。在多变量回归模型中，体重指数是所有种族/民族中CRP浓度升高的显著预测因子（p < 0.001），体重指数对照显著减弱了种族/民族中CRP水平的差异，特别是黑人女性。控制所有测量的可改变的心血管疾病危险因素并不能完全解释CRP的差异。在这些女性中，CRP水平的分布在不同种族/民族之间差异显著。(C)2004年，Excerpta Medica，Inc.
The distribution of C-reactive protein (CRP) levels was compared among 24,455 white, 475 black, 357 Asian, and 254 Hispanic women, all of whom are participants in the Women's Health Study. Median CRP levels were significantly higher among black women (2.96 mg/L, interquartile range [IQR] 1.19 to 5.86) than among their white (2.02 mg/L, IQR 0.81 to 4.37), Hispanic (2.06 mg/L, IQR 0.88 to 4.88), and Asian (1.12 mg/L, IQR 0.48 to 2.25) counterparts. As expected, women taking hormone replacement therapy had higher baseline CRP levels than women not taking hormone replacement therapy. No differences in low-density lipoprotein cholesterol or total cholesterol levels were observed between ethnic groups. In multivariate regression models, body mass index was a significant (p < 0.001) predictor of elevated CRP concentrations among all race/ethnic groups, and control for body m ass index substantially attenuated the differences noted in CRP levels across race/ethnic groups, particularly among black women. Control for all measured modifiable risk factors for cardiovascular disease did not entirely explain CRP differences. Among these women, the distribution of CRP levels varied significantly between the various race/ethnic groups. (C) 2004 by Excerpta Medica, Inc.