Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril
Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril
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DOI：
10.1111/j.1469-7793.1999.897ab.x
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发表时间：
1999-03-15
影响因子：
5.5
通讯作者：
McMillen, IC
中科院分区：
文献类型：
--
作者：
Edwards, LJ;Simonetta, G;McMillen, IC
1.我们测量了动脉血压115和145天之间的妊娠正常生长的胎羊（对照组; n = 16）和胎羊的生长受到限制的胎盘生长和发育的实验限制（PR组; n = 13）。PR组（42.7 +/- 2.6 mmHg）和对照组（37.7 +/- 2.3 mmHg）之间的平均妊娠动脉血压没有显着差异。对照组平均动脉压与动脉血氧分压呈显著正相关（r = 0.53，P < 0.05，n = 16），PR组无相关性.在妊娠115 - 125天，PR组和对照组的平均动脉压对卡托普利的反应均无变化（7.5 μ g/min; PR组n = 7，对照组n = 6）。妊娠135天后，PR组胎儿动脉血压明显下降（P < 0.05），而对照组胎儿动脉血压无明显下降（PR组n = 7，对照组n = 6）.在PR组和对照组中，增加血管紧张素II剂量对胎儿舒张压有显著影响（F = 14.75; P < 0.001）。PR组和对照组在两个胎龄范围内血管紧张素II的作用无差异（F = 8.67; P < 0.05）.这些数据表明，在生长受限胎儿和正常生长的胎儿中，动脉血压可能通过不同的机制维持，并表明胎儿肾素-血管紧张素系统在维持生长受限胎儿血压中的作用。
1. We have measured arterial blood pressure between 115 and 145 days gestation in normally grown fetal sheep (control group; n = 16) and in fetal sheep in which growth was restricted by experimental restriction of placental growth and development (PR group; n = 13). There was no significant difference in the mean gestational arterial blood pressure between the PR (42.7 +/- 2.6 mmHg) and control groups (37.7 +/- 2.3 mmHg). Mean arterial blood pressure and arterial P-O2 were significantly correlated in control animals (r = 0.53, P < 0.05, n = 16), but not in the PR, group.2. There were no changes in mean arterial blood pressure in either the PR or control groups in response to captopril (7.5 mu g captopril min(-1); PR group n = 7, control group n = 6) between 115 and 125 days gestation. After 135 days gestation, there was a significant decrease (P < 0.05) in the fetal arterial blood pressure in the PR group but not in the control group during the captopril infusion (15 mu g captopril min(-1); PR group n = 7, control group n = 6).3. There was a significant effect (F = 14.75; P < 0.001) of increasing doses of angiotensin II on fetal diastolic blood pressure in the PR and control groups. The effects of angiotensin II n ere different (F = 8.67; P < 0.05) in the PR and control groups at both gestational age ranges.4. These data indicate that arterial blood pressure may be maintained by different mechanisms in growth restricted fetuses and normally grown counterparts and suggests a role for the fetal renin-angiotensin system in the maintenance of blood pressure in growth restricted fetuses.