The yoga of Rag GTPases: Dynamic structural poses confer amino acid sensing by mTORC1.
The yoga of Rag GTPases: Dynamic structural poses confer amino acid sensing by mTORC1.
复制标题
DOI：
10.1016/j.jbc.2021.101103
复制
发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Fingar DC
中科院分区：
文献类型：
--
作者：
Fingar DC
Heterodimeric Rag GTPases play a critical role in relaying fluctuating levels of cellular amino acids to the sensor mechanistic target of rapamycin complex 1. Important mechanistic questions remain unresolved, however, regarding how guanine nucleotide binding enables Rag GTPases to transition dynamically between distinct yoga-like structural poses that control activation state. Egri and Shen identified a critical interdomain hydrogen bond within RagA and RagC that stabilizes their GDP-bound states. They demonstrate that this long-distance interaction controls Rag structure and function to confer appropriate amino acid sensing by mechanistic target of rapamycin complex 1.
登录
查看更多内容
影响因子：
16
作者：
Shen K;Choe A;Sabatini DM
通讯作者：
Sabatini DM
影响因子：
4.8
作者：
Jeong, Jae-Hee;Lee, Kwang-Hoon;Kim, Yeon-Gil
通讯作者：
Kim, Yeon-Gil
Gtr1p-Gtr2p 复合物的晶体结构揭示了氨基酸诱导的 TORC1 激活的新见解
影响因子：
10.5
作者：
Gong, Rui;Li, Li;Xu, Yanhui
通讯作者：
Xu, Yanhui
影响因子：
21.3
作者：
Kim, Eunjung;Goraksha-Hicks, Pankuri;Li, Li;Neufeld, Thomas P.;Guan, Kun-Liang
通讯作者：
Guan, Kun-Liang
影响因子：
56.9
作者：
Sancak, Yasemin;Peterson, Timothy R.;Sabatini, David M.
通讯作者：
Sabatini, David M.