Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells
Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells
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DOI：
10.1126/science.289.5485.1754
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发表时间：
2000-09-08
期刊：
影响因子：
56.9
通讯作者：
Raff, M
中科院分区：
文献类型：
--
作者：
Kondo, T;Raff, M
在动物发育过程中，细胞能够分化成的细胞类型变得越来越受限。例如，在中枢神经系统（CNS）中，多潜能干细胞会产生各种特定的前体细胞，这些前体细胞在终末分化为神经元或神经胶质细胞之前会进行有限次数的分裂。我们在此表明，某些细胞外信号能够诱导少突胶质细胞前体细胞恢复为多潜能神经干细胞，这种多潜能神经干细胞能够自我更新，并分化为神经元、星形胶质细胞以及少突胶质细胞。因此，这些前体细胞具有比之前所认为的更大的发育潜能。
During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cells produce various kinds of specified precursors that divide a limited number of times before they terminally differentiate into either neurons OF glial cells. We show here that certain extracellular signals can induce oligodendrocyte precursor cells to revert to multipotential neural stem cells, which can self-renew and give rise to neurons and astrocytes, as well as to oligodendrocytes, Thus, these precursor cells have greater developmental potential than previously thought.