Spontaneously acquired factor IX inhibitor in a nonhemophiliac child
Spontaneously acquired factor IX inhibitor in a nonhemophiliac child
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非血友病儿童自发获得因子 IX 抑制剂
DOI：
10.1016/s0022-3476(78)80502-2
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
J. R. Edson
中科院分区：
文献类型：
--
作者：
K. Miller;J. Neely;W. Krivit;J. R. Edson
一名2岁半以前健康的儿童由于自发获得的因子IX抑制剂而出现左腿进行性肿胀和前胸壁血肿，并伴有血红蛋白浓度下降。她的病情得到了成功的治疗，需要进行四容量的交换输血和免疫抑制治疗，包括环磷酰胺四天和泼尼松一个月。还简要回顾了有关获得性凝血因子、抑制剂的发生和性质以及免疫抑制治疗的作用的文献。
A 2 1/2-year-old, previously healthy child developed progressive swelling of the left leg and a hematoma of the anterior chest wall associated with a falling hemoglobin concentration, as a result of a spontaneously acquired Factor IX inhibitor. Successful management of her condition, required a fourvolume exchange transfusion and immunosuppressive therapy consisting of cyclophosphamide for four days and prednisone for one month. A brief review of the literature regarding the occurrence and nature of acquired coagulation factor, inhibitors and the role of immunosuppressive therapy is also presented.