Sex differences in the cerebral BOLD signal response to painful heat stimuli
Sex differences in the cerebral BOLD signal response to painful heat stimuli
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DOI：
10.1152/ajpregu.00084.2006
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发表时间：
2006-08-01
影响因子：
2.8
通讯作者：
Greenspan, Joel D.
中科院分区：
文献类型：
--
作者：
Moulton, Eric A.;Keaser, Michael L.;Greenspan, Joel D.
关于与疼痛相关的大脑处理过程中的性别差异问题，数据有限。这项研究考察了在相同的疼痛感知条件下，功能磁共振成像(FMRI)测量的疼痛相关血氧水平依赖(BOLD)信号变化是否表现出性别差异。28名健康志愿者(17名女性，11名男性)接受了fMRI扫描，同时对左脚背部施加伤害性热刺激。在所有受试者的几个伤害性感兴趣区(ROI)都观察到了显著的BOLD信号调制。在任何ROI中，BOLD信号变化的空间范围没有性别差异，但大多数ROI中女性的信号幅度较低，初级躯体感觉皮质(S1)、扣带中前皮质和背外侧前额叶皮质(DLPFC)的信号幅度明显较低。大胆的信号反应可能是积极的，也可能是消极的，而且通常在一个ROI内观察到这两个极性。在大多数感兴趣区中，女性比男性表现出更多具有负信号变化的体素，这一差异在S1和DLPFC中具有统计学意义。负面信号变化的时间进程与正面信号变化的时间进程非常相似，表明后者并没有“驱动”前者。负星团和正星团的位置在几个ROI中形成了不同的模式，这些模式表明了一些不同于局部“窃取”现象的东西，作为对负信号变化的解释。基线脑血流的性别差异可能是本研究观察到的BOLD信号差异的原因之一。
There are limited data addressing the question of sex differences in pain-related cerebral processing. This study examined whether pain-related blood oxygenation level-dependent (BOLD) signal change measured with functional magnetic resonance imaging (fMRI) demonstrated sex differences, under conditions of equivalent pain perception. Twenty-eight healthy volunteers (17 women, 11 men) were subject to a fMRI scan while noxious heat stimuli were applied to the dorsum of the left foot. Significant BOLD signal modulation was observed in several nociceptive processing regions of interest (ROIs) in all subjects. There were no sex differences in the spatial extent of BOLD signal change for any ROI, but the signal amplitude was lower for women in most ROIs and significantly so for the primary somatosensory cortex (S1), the midanterior cingulate cortex, and the dorsolateral prefrontal cortex (DLPFC). The BOLD signal response could be positive or negative, and frequently, both polarities were observed within a single ROI. In most ROIs, women show proportionately more voxels with negative signal change than men, and this difference was statistically significant for the S1 and the DLPFC. The time course of the negative signal change was very similar to that of the positive signal change, suggesting that the latter was not "driving" the former. The location of negative and positive clusters formed distinct patterns in several of the ROIs, and these patterns suggest something other than a local "steal" phenomenon as an explanation for the negative signal changes. Sex differences in baseline cerebral blood flow may contribute to the BOLD signal differences observed in this study.