Appendicular Bone Density and Age Predict Hip Fracture in Women

Appendicular Bone Density and Age Predict Hip Fracture in Women
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附肢骨密度和年龄可预测女性髋部骨折

DOI:
10.1001/jama.1990.03440050059033
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发表时间:
1990
期刊:
JAMA
影响因子:
--
通讯作者:
T. Vogt
T. Vogt
中科院分区:
--
文献类型:
--
作者:
S. Cummings;D. Black;M. Nevitt;W. Browner;J. Cauley;H. Genant;S. Mascioli;J. Scott;D. Seeley;P. Steiger;T. Vogt

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为了确定骨密度测量是否可以预测女性髋部骨折,我们前瞻性研究了 9703 名 65 岁及以上的非黑人女性,她们使用单光子吸收法测量了跟骨、桡骨远端和桡骨近端的骨矿物质密度。在平均 1.6 年的随访期间,发生了 53 例髋部骨折。髋部骨折的风险与所有三个测量部位的骨密度呈负相关。调整年龄后,跟骨骨密度每降低 1 个 SD,髋部骨折的相对风险为 1.66(95% 置信区间,1.22 至 2.26),远端桡骨骨密度为 1.55(95% 置信区间,1.13 至 2.11),近端桡骨骨密度为 1.41(95% 置信区间,1.06 至 1.88)。这三个测量值都不是比其他测量值更好的髋部骨折预测指标。调整骨矿物质密度后,年龄每增加 10 岁,髋部骨折的风险就会增加一倍(相对风险,2.09;95% 置信区间,1.31 至 3.33)。我们的结论是,四肢骨骼骨密度降低与髋部骨折风险增加有关,但这只是老年女性髋部骨折风险随年龄增加而增加的部分原因。 (美国医学会杂志。1990;263:665-668)
To determine whether measurement of bone density predicts hip fracture in women, we prospectively studied 9703 nonblack women aged 65 years and older who had measurements of bone mineral density using single-photon absorptiometry in the calcaneus, distal radius, and proximal radius. During an average of 1.6 years of follow-up, 53 hip fractures occurred. The risk of hip fracture was inversely related to bone density at all three measurement sites. After adjusting for age, the relative risk of hip fracture was 1.66 for a decrease of 1 SD in the bone density at the calcaneus (95% confidence interval, 1.22 to 2.26), 1.55 (95% confidence interval, 1.13 to 2.11) at the distal radius, and 1.41 (95% confidence interval, 1.06 to 1.88) at the proximal radius. None of the three measurements was a significantly better predictor of hip fracture than the others. After adjusting for bone mineral density, the risk of hip fracture doubled for each 10-year increase in age (relative risk, 2.09; 95% confidence interval, 1.31 to 3.33). We conclude that decreased bone density in the appendicular skeleton is associated with an increased risk of hip fracture, but this accounts for only part of the age-related increase in risk of hip fracture among older women. ( JAMA . 1990;263:665-668)
DOI: 10.1016/8756-3282(87)90001-9
发表时间: 1987
期刊: Bone
影响因子: 4.1
作者:
Ross,PD;Wasnich,RD;Heilbrun,LK;Vogel,JM
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跌倒后受伤的危险因素。
DOI: --
发表时间: 1985
影响因子: 3.3
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选择用于骨折风险预测的最佳骨骼部位。
DOI: --
发表时间: 1987
影响因子: 4.2
作者:
Wasnich,RD;Ross,PD;Heilbrun,LK;Vogel,JM
通讯作者: Vogel,JM
DOI: --
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期刊: --
影响因子: --
作者:
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DOI: 10.1016/0002-9378(85)90338-2
发表时间: 1985
影响因子: 9.8
作者:
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