Role of Calcium sensing receptor (CaSR) in tumorigenesis
Role of Calcium sensing receptor (CaSR) in tumorigenesis
复制标题
DOI：
10.1016/j.beem.2013.04.001
复制
发表时间：
2013-06-01
影响因子：
7.4
通讯作者：
Chakrabarty, Subhas
中科院分区：
文献类型：
--
作者：
Singh, Navneet;Promkan, Moltira;Chakrabarty, Subhas
细胞外Ca2+敏感受体（CaSR）是结肠上皮细胞分化的强有力促进剂，并在结肠癌中起肿瘤抑制剂的作用。CaSR通过多种机制介导其生物学效应。CaSR表达的缺失激活了无数的干细胞样分子特征，这些特征驱动并维持结肠癌的恶性和耐药表型。然而，这种CaSR无效表型不是不可逆的，并且在CaSR无效细胞中诱导CaSR表达促进细胞死亡机制并恢复药物敏感性。CaSR还在乳腺癌中起肿瘤抑制剂的作用，并促进细胞对细胞毒性药物的敏感性。BRCA1和CaSR功能在乳腺癌细胞中交叉，CaSR激活可以将乳腺癌细胞从BRCA1突变的有害影响中拯救出来。(C)2013爱思唯尔有限公司保留所有权利。
The extracellular Ca2+-sensing receptor (CaSR) is a robust promoter of differentiation in colonic epithelial cells and functions as a tumor suppressor in colon cancer. CaSR mediates its biologic effects through diverse mechanisms. Loss of CaSR expression activates a myriad of stem cell-like molecular features that drive and sustain the malignant and drug-resistant phenotypes of colon cancer. This CaSR-null phenotype, however, is not irreversible and induction of CaSR expression in CaSR-null cells promotes cell death mechanisms and restores drug sensitivity. The CaSR also functions as a tumor suppressor in breast cancer and promotes cellular sensitivity to cytotoxic drugs. BRCA1 and CaSR functions intersect in breast cancer cells, and CaSR activation can rescue breast cancer cells from the deleterious effect of BRCA1 mutations. (C) 2013 Elsevier Ltd. All rights reserved.