Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims.
Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims.
复制标题
严重抑郁症自杀者的皮质表达增加了 RNA 编辑酶。
DOI：
10.1097/wnr.0b013e32833f11c3
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发表时间：
2010
期刊：
影响因子：
1.7
通讯作者：
Sodhi,MonsheelS
中科院分区：
文献类型：
--
作者：
Simmons,Micah;Meador-Woodruff,JamesH;Sodhi,MonsheelS
RNA编辑是一个转录后过程，它严重调节调节情绪，焦虑，学习和记忆的几种神经递质受体的功能。几项尸检研究的数据显示，心境障碍和自杀患者的5-羟色胺-2C受体RNA编辑增加，因此预计这些患者的5-羟色胺-2C受体信号转导可能减少。在这项研究中，我们已经测试了这样的假设，即催化RNA编辑的酶，作用于RNA 1的腺苷脱氨酶（ADAR 1）和ADAR 2的表达水平在自杀中也异常。在来自Stanley Consortium Brain系列的个体的背外侧前额叶皮层中测量基因表达，所述Stanley Consortium Brain系列包括患有精神分裂症（n = 15）、重性抑郁症（n = 15）、双相情感障碍（n= 15）和对照组（n= 14）的患者。在这些精神病患者中，有20人是自杀者。研究发现，与没有自杀的患者相比，重度抑郁症自杀患者的ADAR 1表达显著增加。ADAR 1和ADAR 2的表达在任何其他诊断组中均未改变。这些数据表明，ADAR 1可能在抑郁症患者自杀的病理生理学中发挥作用。
RNA editing is a posttranscriptional process which critically modulates the function of several neurotransmitter receptors regulating mood, anxiety, learning, and memory. Data from several postmortem studies have shown increased 5-hydroxytryptamine-2C receptor RNA editing in mood disorders and suicide, and therefore the 5-hydroxytryptamine-2C receptor might be expected to have reduced signal transduction in these patients. In this study, we have tested the hypothesis that the expression levels of the enzymes which catalyze RNA editing, adenosine deaminase acting on RNA 1 (ADAR1) and ADAR2, are also abnormal in suicide. Gene expression was measured in the dorsolateral prefrontal cortex of individuals from the Stanley Consortium Brain series, which includes patients with schizophrenia (n= 15), major depression (n= 15), bipolar disorder (n= 15), and a comparison group (n= 14). Of the psychiatric patients, 20 were suicide victims. ADAR1 expression was found to be significantly increased in major depressive suicide victims compared with patients who did not commit suicide. Neither ADAR1 nor ADAR2 expression was altered in any of the other diagnostic groups. These data indicate that ADAR1 could play a role in the pathophysiology of suicide in patients with major depression.