Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy
Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy
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DOI：
10.1016/j.clnu.2003.10.010
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发表时间：
2004-08-01
影响因子：
6.3
通讯作者：
Liu, DZ
中科院分区：
文献类型：
--
作者：
Huang, SY;Jeng, C;Liu, DZ
背景和目标：红细胞变形性、血浆粘度、血液粘度、血液粘弹性等血液流变学特性的异常改变在糖尿病微血管病变的发生发展中起重要作用。在这项研究中，我们证明糖尿病患者服用银杏叶提取物761（Egb 761）的改善异常的血液流变学参数。方法：25例2型糖尿病视网膜病变患者口服Egb 761前和3个月后测定血液流变学参数。这些参数包括红细胞的脂质过氧化应激、红细胞变形性、血浆和血液粘度、血液粘弹性和视网膜毛细血管血流速度。口服Egb 761 3个月后，血液粘度在不同切变率下均显著降低，降低幅度为0.44 ± 0.10（γ = 400）、0.52+/-0.09（y = 150）和2.88+/-0.57（γ = 5）。糖尿病患者的粘弹性显著降低3.08+/-0.78（0.1 Hz）。红细胞丙二醛（MDA）含量降低30%，红细胞变形能力提高20%。最后，视网膜毛细血管血流量从3.23+/-0.12增加到3.67+/-0.24 cm min（-1）。在这项初步临床研究中，口服Egb 761 3个月可显著降低红细胞膜MDA水平，降低纤维蛋白原水平，促进红细胞变形能力，改善血液粘度和粘弹性，这可以促进血液灌注。此外，它还能有效改善2型糖尿病视网膜病变患者的视网膜毛细血管血流速度。(C)2003爱思唯尔有限公司。保留所有权利。
Background & Aims: Abnormal haemorrheological property changes in erythrocyte deformability, plasma and blood viscosity, and blood viscoelasticity may play very important roles in the development of microangiopathies in diabetes mellitus (DM). In this study, we demonstrate the improvement in abnormal haemorrheological parameters in DM with ingestion of Ginkgo biloba extract 761 (Egb 761).Methods: Haemorrheological parameters before and 3 months after Egb 761 oral ingestion were determined in 25 type 2 DM patients with retinopathy. These parameters included lipid peroxidation stress of erythrocytes, erythrocyte deformability, plasma and blood viscosity, blood viscoelasticity, and retinal capillary blood flow velocity.Results: After taking Egb 761 orally for 3 months, the blood viscosity was significantly reduced at different shear rates, by 0.44+/-0.10 (gamma = 400), 0.52+/-0.09 (y = 150) and 2.88+/-0.57 (gamma = 5). Viscoelasticity was significantly reduced in diabetic patients by 3.08+/-0.78 (0.1 Hz). The level of erythrocyte malondialdehyde (MDA) was reduced by 30%; however, the deformability of erythrocyte was increased by 20%. And lastly, retinal capillary blood flow rate was increased from 3.23+/-0.12 to 3.67+/-0.24 cm min(-1).Conclusion: In this preliminary clinical study, 3 months of oral administration of Egb 761 significantly reduced MDA levels of erythrocytes membranes, decreased fibrinogen levels, promoted erythrocytes deformability, and improved blood viscosity and viscoelasticity, which may facilitate blood perfusion. Furthermore, it effectively improved retinal capillary blood flow rate in type 2 diabetic patients with retinopathy. (C) 2003 Elsevier Ltd. All rights reserved.