Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma
Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma
复制标题
hsa_circ_0137287 表达降低可预测甲状腺乳头状癌的侵袭性临床病理特征。
DOI：
10.1002/jcla.22573
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发表时间：
2018-10-01
影响因子：
2.7
通讯作者：
Ge, Minghua
中科院分区：
文献类型：
--
作者：
Lan, Xiabin;Cao, Jun;Ge, Minghua
背景方法循环RNA(CircRNA)是一种新型的非编码RNA，可作为理想的生物标志物。有证据表明，CircRNAs在肿瘤的发生和发展中起着重要的作用。然而，CircRNA在甲状腺乳头状癌中的诊断价值及其与临床病理特征的关系尚不清楚。采用实时定量聚合酶链式反应检测了120例甲状腺乳头状癌和60例癌旁非癌甲状腺组织中hSA_CIRC_0137287的表达水平。分析hsA_CIRC_0137287在甲状腺癌中的表达与临床病理因素的关系。结果hSA_CIRC_0137287在甲状腺癌组织中的表达显著低于癌旁组织(P<0.05)。
BackgroundMethodsCircular RNA (circRNA) is a new type of noncoding RNA that can serve as ideal biomarkers. Evidence has showed that circRNAs play an important role in carcinogenesis and cancer development. However, little is known about the diagnostic value of circRNAs in papillary thyroid carcinoma (PTC) as well as their associations with clinicopathologic characteristics of patients with PTC.The expression levels of hsa_circ_0137287 were detected in 120 PTC and 60 adjacent noncancerous thyroid tissues by quantitative real-time polymerase chain reaction. The relationships between the expression of hsa_circ_0137287 in PTC and the clinicopathologic factors were analyzed. Finally, receiver operating characteristic (ROC) curves were generated to assess the diagnostic value of hsa_circ_0137287 as a biomarker for PTC.ResultsConclusionsThe expression of hsa_circ_0137287 was significantly downregulated in PTC tissues compared with adjacent noncancerous tissues (P