The predictors of survival in Chinese amyotrophic lateral sclerosis patients
The predictors of survival in Chinese amyotrophic lateral sclerosis patients
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DOI：
10.3109/21678421.2014.993650
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发表时间：
2015-06-01
影响因子：
2.8
通讯作者：
Shang, Huifang
中科院分区：
文献类型：
--
作者：
Wei, Qianqian;Chen, Xueping;Shang, Huifang
肌萎缩侧索硬化症（ALS）是一种进展迅速的神经退行性疾病，因此研究ALS的生存因素具有重要意义。我们的目的是评估中国ALS患者生存的预测因素。共招募了1049名散发性ALS患者。Kaplan-Meier曲线用于比较生存时间。采用考克斯比例风险函数和风险比确定校正后的预后预测因子。结果显示，平均发病年龄为52.6 ± 12.0岁。随访期间，155例患者（14.8%）失访，378例患者死亡。死亡患者的中位生存期为33个月。在调整后的考克斯比例风险模型中，发病年龄、诊断延迟、疾病进展速度和无创正压通气（NIPPV）治疗对ALS的生存率有影响。总之，我们的研究为中国ALS患者的生存因素提供了信息。虽然中国ALS患者的发病年龄早于白人患者，但生存因素，包括发病年龄、诊断延迟、疾病进展率和NIPPV治疗，是相似的。
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease, so it is important to explore the survival factors for ALS. Our aim was to evaluate the predictors of survival in Chinese ALS patients. A total of 1049 sporadic ALS patients were enrolled. Kaplan-Meier curves were used to compare survival time. Cox proportional hazards function and the hazard ratio were used to identify adjusted prognostic predictors. Results showed that the mean age of onset was 52.6 +/- 12.0 years. During follow-up, 155 patients (14.8%) were lost and 378 patients were deceased. Median survival was 33 months for the deceased patients. In the adjusted Cox proportional hazard model, age of onset, diagnosis delay, rate of disease progression, and non-invasive positive pressure ventilation (NIPPV) treatment had an effect on survival in ALS. In conclusion, our study provides information on survival factors for Chinese ALS patients. Although the onset age of Chinese ALS patients is earlier than that of Caucasian patients, survival factors, including the age of onset, diagnostic delay, rate of disease progression, and NIPPV treatment, are similar.