Mechanism of self-sterility in a hermaphroditic chordate
Mechanism of self-sterility in a hermaphroditic chordate
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DOI：
10.1126/science.1152488
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发表时间：
2008-04-25
期刊：
影响因子：
56.9
通讯作者：
Sawada, Hitoshi
中科院分区：
文献类型：
--
作者：
Harada, Yoshito;Takagaki, Yuhei;Sawada, Hitoshi
两性生物通过自交不亲和系统避免近亲繁殖.原始的脊索动物（海鞘）玻璃海鞘就是这样一种生物的例子，但其SI系统的分子机制尚不清楚。在这里，我们表明SI系统由两个协同作用的基因座控制。每个基因座包含一对紧密相连的多囊蛋白1相关受体（s-Themis）和纤维蛋白原样配体（v-Themis）基因，后者位于s-Themis的第一内含子，但转录方向相反.这些基因可能编码雄性和雌性的自我识别分子. C.植物的结构与开花植物相似，但使用不同的分子。
Hermaphroditic organisms avoid inbreeding by a system of self- incompatibility ( SI). A primitive chordate ( ascidian) Ciona intestinalis is an example of such an organism, but the molecular mechanism underlying its SI system is not known. Here, we show that the SI system is governed by two gene loci that act cooperatively. Each locus contains a tightly linked pair of polycystin 1- related receptor ( s- Themis) and fibrinogen- like ligand ( v- Themis) genes, the latter of which is located in the first intron of s- Themis but transcribed in the opposite direction. These genes may encode male- and female- side self- recognition molecules. The SI system of C. intestinalis has a similar framework to that of flowering plants but utilizing different molecules.