HIGH-DOSE CISPLATIN AND BLEOMYCIN NEOADJUVANT CHEMOTHERAPY PLUS RADICAL SURGERY IN LOCALLY ADVANCED CERVICAL-CARCINOMA - A PRELIMINARY-REPORT
HIGH-DOSE CISPLATIN AND BLEOMYCIN NEOADJUVANT CHEMOTHERAPY PLUS RADICAL SURGERY IN LOCALLY ADVANCED CERVICAL-CARCINOMA - A PRELIMINARY-REPORT
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DOI：
10.1016/0090-8258(91)90310-2
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发表时间：
1991-06-01
影响因子：
4.7
通讯作者：
MANCUSO, S
中科院分区：
文献类型：
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作者：
PANICI, PB;GREGGI, S;MANCUSO, S
对26例先前未治疗的IB期（大体积疾病）-III型宫颈癌患者连续给予一个疗程的含顺铂和博来霉素的化疗作为新辅助治疗，随后进行根治性手术。化疗后，23例患者（5例完全，18例部分，总体88%）有反应，21例（81%）允许根治性手术。手术包括III-IV型根治性子宫切除术加系统腹主动脉旁淋巴结和盆腔淋巴结切除术。在组织学检查中，完全缓解5例（19%），部分缓解16例（62%）。平均切除61个淋巴结（范围38-118）。淋巴结转移的发生率低于预期（21.1%,9.5%）。化疗毒性主要表现为恶心、呕吐。在这些情况下，化疗似乎没有使手术复杂化，尽管48%的病例发生了中度术后并发症。手术患者从生理诊断起随访18个月（范围11-23个月），未发现复发。
One course of chemotherapy containing cisplatin and bleomycin as a neoadjuvant treatment was given to 26 consecutive patients with previously untreated stage IB (bulky disease)-III cervical carcinoma and followed by radical surgery. After chemotherapy responses were detected in 23 patients (5 complete and 18 partial; overall, 88%) and permitted radical surgery in 21 cases (81%). Surgery consisted of type III–IV radical hysterectomy plus systematic para-aortic and pelvic lymphadenectomy. At histologic examination, complete responses were found in 5 (19%) and partial responses in 16 (62%) cases. The average number of lymph nodes removed was 61 (range, 38–118). A lower than expected incidence of lymph node metastases was detected (2 21, 9.5%). The chemotherapy-induced toxicity was mainly represented by nausea and vomiting. Chemotherapy did not seem to complicate surgery in these circumstances, even though moderate-degree postoperative complications occurred in 48% of cases. Eighteen months median follow-up time (range, 11–23) from hystological diagnosis has been reached in the operated patients, and no recurrences have been detected so far.